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Inhibition of the cardiomyocyte-specific kinase TNNI3K limits oxidative stress, injury, and adverse remodeling in the ischemic heart.
Vagnozzi RJ, Gatto GJ Jr, Kallander LS, Hoffman NE, Mallilankaraman K, Ballard VL, Lawhorn BG, Stoy P, Philp J, Graves AP, Naito Y, Lepore JJ, Gao E, Madesh M, Force T. Vagnozzi RJ, et al. Among authors: mallilankaraman k. Sci Transl Med. 2013 Oct 16;5(207):207ra141. doi: 10.1126/scitranslmed.3006479. Sci Transl Med. 2013. PMID: 24132636 Free PMC article.
S-glutathionylation activates STIM1 and alters mitochondrial homeostasis.
Hawkins BJ, Irrinki KM, Mallilankaraman K, Lien YC, Wang Y, Bhanumathy CD, Subbiah R, Ritchie MF, Soboloff J, Baba Y, Kurosaki T, Joseph SK, Gill DL, Madesh M. Hawkins BJ, et al. Among authors: mallilankaraman k. J Cell Biol. 2010 Aug 9;190(3):391-405. doi: 10.1083/jcb.201004152. Epub 2010 Aug 2. J Cell Biol. 2010. PMID: 20679432 Free PMC article.
NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis.
Thapa RJ, Basagoudanavar SH, Nogusa S, Irrinki K, Mallilankaraman K, Slifker MJ, Beg AA, Madesh M, Balachandran S. Thapa RJ, et al. Among authors: mallilankaraman k. Mol Cell Biol. 2011 Jul;31(14):2934-46. doi: 10.1128/MCB.05445-11. Epub 2011 May 16. Mol Cell Biol. 2011. PMID: 21576359 Free PMC article.
Requirement of FADD, NEMO, and BAX/BAK for aberrant mitochondrial function in tumor necrosis factor alpha-induced necrosis.
Irrinki KM, Mallilankaraman K, Thapa RJ, Chandramoorthy HC, Smith FJ, Jog NR, Gandhirajan RK, Kelsen SG, Houser SR, May MJ, Balachandran S, Madesh M. Irrinki KM, et al. Among authors: mallilankaraman k. Mol Cell Biol. 2011 Sep;31(18):3745-58. doi: 10.1128/MCB.05303-11. Epub 2011 Jul 11. Mol Cell Biol. 2011. PMID: 21746883 Free PMC article.
Hypoxia-induced acidosis uncouples the STIM-Orai calcium signaling complex.
Mancarella S, Wang Y, Deng X, Landesberg G, Scalia R, Panettieri RA, Mallilankaraman K, Tang XD, Madesh M, Gill DL. Mancarella S, et al. Among authors: mallilankaraman k. J Biol Chem. 2011 Dec 30;286(52):44788-98. doi: 10.1074/jbc.M111.303081. Epub 2011 Nov 14. J Biol Chem. 2011. PMID: 22084246 Free PMC article.
MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism.
Mallilankaraman K, Cárdenas C, Doonan PJ, Chandramoorthy HC, Irrinki KM, Golenár T, Csordás G, Madireddi P, Yang J, Müller M, Miller R, Kolesar JE, Molgó J, Kaufman B, Hajnóczky G, Foskett JK, Madesh M. Mallilankaraman K, et al. Nat Cell Biol. 2012 Dec;14(12):1336-43. doi: 10.1038/ncb2622. Epub 2012 Nov 25. Nat Cell Biol. 2012. PMID: 23178883 Free PMC article.
45 results