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CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, Owens TW, Peters JK, Rizo AN, Schulze-Gahmen U, Smith AM, Young ID, Yu Z, Asarnow D, Billesbølle C, Campbell MG, Chen J, Chen KH, Chio US, Dickinson MS, Doan L, Jin M, Kim K, Li J, Li YL, Linossi E, Liu Y, Lo M, Lopez J, Lopez KE, Mancino A, Moss FR 3rd, Paul MD, Pawar KI, Pelin A, Pospiech TH Jr, Puchades C, Remesh SG, Safari M, Schaefer K, Sun M, Tabios MC, Thwin AC, Titus EW, Trenker R, Tse E, Tsui TKM, Wang F, Zhang K, Zhang Y, Zhao J, Zhou F, Zhou Y, Zuliani-Alvarez L; QCRG Structural Biology Consortium; Agard DA, Cheng Y, Fraser JS, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Swaney DL, Krogan NJ, Frost A, Rosenberg OS, Verba KA. Gupta M, et al. Among authors: jura n. bioRxiv [Preprint]. 2021 May 11:2021.05.10.443524. doi: 10.1101/2021.05.10.443524. bioRxiv. 2021. PMID: 34013269 Free PMC article. Preprint.
Drugging the "Undruggable" MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers.
Wolpaw AJ, Bayliss R, Büchel G, Dang CV, Eilers M, Gustafson WC, Hansen GH, Jura N, Knapp S, Lemmon MA, Levens D, Maris JM, Marmorstein R, Metallo SJ, Park JR, Penn LZ, Rape M, Roussel MF, Shokat KM, Tansey WP, Verba KA, Vos SM, Weiss WA, Wolf E, Mossé YP. Wolpaw AJ, et al. Among authors: jura n. Cancer Res. 2021 Apr 1;81(7):1627-1632. doi: 10.1158/0008-5472.CAN-20-3108. Epub 2021 Jan 28. Cancer Res. 2021. PMID: 33509943 Free PMC article. Review.
Mutant HER2 needs mutant HER3 to be an effective oncogene.
Trenker R, Diwanji D, Jura N. Trenker R, et al. Among authors: jura n. Cell Rep Med. 2021 Aug 6;2(8):100361. doi: 10.1016/j.xcrm.2021.100361. eCollection 2021 Aug 17. Cell Rep Med. 2021. PMID: 34467245 Free PMC article.
Targetable HER3 functions driving tumorigenic signaling in HER2-amplified cancers.
Campbell MR, Ruiz-Saenz A, Peterson E, Agnew C, Ayaz P, Garfinkle S, Littlefield P, Steri V, Oeffinger J, Sampang M, Shan Y, Shaw DE, Jura N, Moasser MM. Campbell MR, et al. Among authors: jura n. Cell Rep. 2022 Feb 1;38(5):110291. doi: 10.1016/j.celrep.2021.110291. Cell Rep. 2022. PMID: 35108525 Free PMC article.
EGFR lung cancer mutants get specialized.
Littlefield P, Jura N. Littlefield P, et al. Among authors: jura n. Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15169-70. doi: 10.1073/pnas.1314719110. Epub 2013 Sep 10. Proc Natl Acad Sci U S A. 2013. PMID: 24023066 Free PMC article. No abstract available.
Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras.
Liang SI, van Lengerich B, Eichel K, Cha M, Patterson DM, Yoon TY, von Zastrow M, Jura N, Gartner ZJ. Liang SI, et al. Among authors: jura n. Cell Rep. 2018 Mar 6;22(10):2593-2600. doi: 10.1016/j.celrep.2018.02.031. Cell Rep. 2018. PMID: 29514089 Free PMC article.
81 results