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c-Kit-positive cardiac stem cells nested in hypoxic niches are activated by stem cell factor reversing the aging myopathy.
Sanada F, Kim J, Czarna A, Chan NY, Signore S, Ogórek B, Isobe K, Wybieralska E, Borghetti G, Pesapane A, Sorrentino A, Mangano E, Cappetta D, Mangiaracina C, Ricciardi M, Cimini M, Ifedigbo E, Perrella MA, Goichberg P, Choi AM, Kajstura J, Hosoda T, Rota M, Anversa P, Leri A. Sanada F, et al. Among authors: anversa p. Circ Res. 2014 Jan 3;114(1):41-55. doi: 10.1161/CIRCRESAHA.114.302500. Epub 2013 Oct 29. Circ Res. 2014. PMID: 24170267 Free PMC article.
Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival.
Urbanek K, Rota M, Cascapera S, Bearzi C, Nascimbene A, De Angelis A, Hosoda T, Chimenti S, Baker M, Limana F, Nurzynska D, Torella D, Rotatori F, Rastaldo R, Musso E, Quaini F, Leri A, Kajstura J, Anversa P. Urbanek K, et al. Among authors: anversa p. Circ Res. 2005 Sep 30;97(7):663-73. doi: 10.1161/01.RES.0000183733.53101.11. Epub 2005 Sep 1. Circ Res. 2005. PMID: 16141414
Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc gene.
Rota M, LeCapitaine N, Hosoda T, Boni A, De Angelis A, Padin-Iruegas ME, Esposito G, Vitale S, Urbanek K, Casarsa C, Giorgio M, Lüscher TF, Pelicci PG, Anversa P, Leri A, Kajstura J. Rota M, et al. Among authors: anversa p. Circ Res. 2006 Jul 7;99(1):42-52. doi: 10.1161/01.RES.0000231289.63468.08. Epub 2006 Jun 8. Circ Res. 2006. PMID: 16763167
The young mouse heart is composed of myocytes heterogeneous in age and function.
Rota M, Hosoda T, De Angelis A, Arcarese ML, Esposito G, Rizzi R, Tillmanns J, Tugal D, Musso E, Rimoldi O, Bearzi C, Urbanek K, Anversa P, Leri A, Kajstura J. Rota M, et al. Among authors: anversa p. Circ Res. 2007 Aug 17;101(4):387-99. doi: 10.1161/CIRCRESAHA.107.151449. Epub 2007 Jun 29. Circ Res. 2007. PMID: 17601802
Activation of cardiac progenitor cells reverses the failing heart senescent phenotype and prolongs lifespan.
Gonzalez A, Rota M, Nurzynska D, Misao Y, Tillmanns J, Ojaimi C, Padin-Iruegas ME, Müller P, Esposito G, Bearzi C, Vitale S, Dawn B, Sanganalmath SK, Baker M, Hintze TH, Bolli R, Urbanek K, Hosoda T, Anversa P, Kajstura J, Leri A. Gonzalez A, et al. Among authors: anversa p. Circ Res. 2008 Mar 14;102(5):597-606. doi: 10.1161/CIRCRESAHA.107.165464. Epub 2008 Jan 17. Circ Res. 2008. Retraction in: Circ Res. 2019 Feb 15;124(4):e20. doi: 10.1161/RES.0000000000000244. PMID: 18202313 Retracted.
Local activation or implantation of cardiac progenitor cells rescues scarred infarcted myocardium improving cardiac function.
Rota M, Padin-Iruegas ME, Misao Y, De Angelis A, Maestroni S, Ferreira-Martins J, Fiumana E, Rastaldo R, Arcarese ML, Mitchell TS, Boni A, Bolli R, Urbanek K, Hosoda T, Anversa P, Leri A, Kajstura J. Rota M, et al. Among authors: anversa p. Circ Res. 2008 Jul 3;103(1):107-16. doi: 10.1161/CIRCRESAHA.108.178525. Epub 2008 Jun 12. Circ Res. 2008. PMID: 18556576 Free PMC article.
Cardiac stem cells and myocardial disease.
Kajstura J, Urbanek K, Rota M, Bearzi C, Hosoda T, Bolli R, Anversa P, Leri A. Kajstura J, et al. Among authors: anversa p. J Mol Cell Cardiol. 2008 Oct;45(4):505-13. doi: 10.1016/j.yjmcc.2008.05.025. Epub 2008 Jun 13. J Mol Cell Cardiol. 2008. PMID: 18598700 Review.
383 results