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Polycystin-1 but not polycystin-2 deficiency causes upregulation of the mTOR pathway and can be synergistically targeted with rapamycin and metformin.
Mekahli D, Decuypere JP, Sammels E, Welkenhuyzen K, Schoeber J, Audrezet MP, Corvelyn A, Dechênes G, Ong AC, Wilmer MJ, van den Heuvel L, Bultynck G, Parys JB, Missiaen L, Levtchenko E, De Smedt H. Mekahli D, et al. Among authors: schoeber j. Pflugers Arch. 2014 Aug;466(8):1591-604. doi: 10.1007/s00424-013-1394-x. Epub 2013 Nov 6. Pflugers Arch. 2014. PMID: 24193408
Cystinosis: practical tools for diagnosis and treatment.
Wilmer MJ, Schoeber JP, van den Heuvel LP, Levtchenko EN. Wilmer MJ, et al. Among authors: schoeber jp. Pediatr Nephrol. 2011 Feb;26(2):205-15. doi: 10.1007/s00467-010-1627-6. Epub 2010 Aug 24. Pediatr Nephrol. 2011. PMID: 20734088 Free PMC article. Review.
Genetic disorders of renal phosphate transport.
Levtchenko E, Schoeber J, Jaeken J. Levtchenko E, et al. Among authors: schoeber j. N Engl J Med. 2010 Oct 28;363(18):1774; author reply 1774-5. doi: 10.1056/NEJMc1008407. N Engl J Med. 2010. PMID: 21038516 Free article. No abstract available.
Deficiency of either P-glycoprotein or breast cancer resistance protein protect against acute kidney injury.
Huls M, Schoeber JP, Verfaillie CM, Luttun A, Ulloa-Montoya F, Menke AL, van Bolderen LR, Woestenenk RM, Merkx GF, Wetzels JF, Russel FG, Masereeuw R. Huls M, et al. Among authors: schoeber jp. Cell Transplant. 2010;19(9):1195-208. doi: 10.3727/096368910X504478. Epub 2010 May 4. Cell Transplant. 2010. Retraction in: Cell Transplant. 2021 Jan-Dec;30:9636897211031022. doi: 10.1177/09636897211031022 PMID: 20977831 Free article. Retracted.
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