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337 results

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Page 1
mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome.
Johnson SC, Yanos ME, Kayser EB, Quintana A, Sangesland M, Castanza A, Uhde L, Hui J, Wall VZ, Gagnidze A, Oh K, Wasko BM, Ramos FJ, Palmiter RD, Rabinovitch PS, Morgan PG, Sedensky MM, Kaeberlein M. Johnson SC, et al. Among authors: rabinovitch ps. Science. 2013 Dec 20;342(6165):1524-8. doi: 10.1126/science.1244360. Epub 2013 Nov 14. Science. 2013. PMID: 24231806 Free PMC article.
Extension of murine life span by overexpression of catalase targeted to mitochondria.
Schriner SE, Linford NJ, Martin GM, Treuting P, Ogburn CE, Emond M, Coskun PE, Ladiges W, Wolf N, Van Remmen H, Wallace DC, Rabinovitch PS. Schriner SE, et al. Among authors: rabinovitch ps. Science. 2005 Jun 24;308(5730):1909-11. doi: 10.1126/science.1106653. Epub 2005 May 5. Science. 2005. PMID: 15879174
Medicine: grapes versus gluttony.
Kaeberlein M, Rabinovitch PS. Kaeberlein M, et al. Among authors: rabinovitch ps. Nature. 2006 Nov 16;444(7117):280-1. doi: 10.1038/nature05308. Nature. 2006. PMID: 17086197 No abstract available.
Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A.
Enns LC, Morton JF, Mangalindan RS, McKnight GS, Schwartz MW, Kaeberlein MR, Kennedy BK, Rabinovitch PS, Ladiges WC. Enns LC, et al. Among authors: rabinovitch ps. J Gerontol A Biol Sci Med Sci. 2009 Dec;64(12):1221-31. doi: 10.1093/gerona/glp133. Epub 2009 Sep 23. J Gerontol A Biol Sci Med Sci. 2009. PMID: 19776218 Free PMC article.
Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure.
Dai DF, Johnson SC, Villarin JJ, Chin MT, Nieves-Cintrón M, Chen T, Marcinek DJ, Dorn GW 2nd, Kang YJ, Prolla TA, Santana LF, Rabinovitch PS. Dai DF, et al. Among authors: rabinovitch ps. Circ Res. 2011 Apr 1;108(7):837-46. doi: 10.1161/CIRCRESAHA.110.232306. Epub 2011 Feb 10. Circ Res. 2011. PMID: 21311045 Free PMC article.
Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.
Ramos FJ, Chen SC, Garelick MG, Dai DF, Liao CY, Schreiber KH, MacKay VL, An EH, Strong R, Ladiges WC, Rabinovitch PS, Kaeberlein M, Kennedy BK. Ramos FJ, et al. Among authors: rabinovitch ps. Sci Transl Med. 2012 Jul 25;4(144):144ra103. doi: 10.1126/scitranslmed.3003802. Sci Transl Med. 2012. PMID: 22837538 Free PMC article.
mTOR is a key modulator of ageing and age-related disease.
Johnson SC, Rabinovitch PS, Kaeberlein M. Johnson SC, et al. Among authors: rabinovitch ps. Nature. 2013 Jan 17;493(7432):338-45. doi: 10.1038/nature11861. Nature. 2013. PMID: 23325216 Free PMC article. Review.
Molecular mechanisms underlying genotype-dependent responses to dietary restriction.
Schleit J, Johnson SC, Bennett CF, Simko M, Trongtham N, Castanza A, Hsieh EJ, Moller RM, Wasko BM, Delaney JR, Sutphin GL, Carr D, Murakami CJ, Tocchi A, Xian B, Chen W, Yu T, Goswami S, Higgins S, Holmberg M, Jeong KS, Kim JR, Klum S, Liao E, Lin MS, Lo W, Miller H, Olsen B, Peng ZJ, Pollard T, Pradeep P, Pruett D, Rai D, Ros V, Singh M, Spector BL, Vander Wende H, An EH, Fletcher M, Jelic M, Rabinovitch PS, MacCoss MJ, Han JD, Kennedy BK, Kaeberlein M. Schleit J, et al. Among authors: rabinovitch ps. Aging Cell. 2013 Dec;12(6):1050-61. doi: 10.1111/acel.12130. Epub 2013 Aug 11. Aging Cell. 2013. PMID: 23837470 Free PMC article.
337 results