Lin H - Search Results

1

A novel approach applying a chemical biology strategy in phenotypic screening reveals pathway-selective regulators of histone 3 K27 tri-methylation.

Liu Y, Platchek M, Kement B, Bee WT, Truong M, Zeng X, Hung S, Lin H, Morrow D, Kallal LA, Xie Q, Agarwal P, Pope AJ, Wu Z. Liu Y, et al. Among authors: lin h. Mol Biosyst. 2014 Feb;10(2):251-7. doi: 10.1039/c3mb70413k. Mol Biosyst. 2014. PMID: 24257700

2

A High-Content Imaging Screen for Cellular Regulators of β-Catenin Protein Abundance.

Zeng X, Montoute M, Bee TW, Lin H, Kallal LA, Liu Y, Agarwal P, Wang D, Lu Q, Morrow D, Pope AJ, Wu Z. Zeng X, et al. Among authors: lin h. J Biomol Screen. 2016 Mar;21(3):260-8. doi: 10.1177/1087057115620169. Epub 2015 Dec 9. J Biomol Screen. 2016. PMID: 26656867

3

A Novel Neuroprotective Small Molecule for Glial Cell Derived Neurotrophic Factor Induction and Photoreceptor Rescue.

Baranov P, Lin H, McCabe K, Gale D, Cai S, Lieppman B, Morrow D, Lei P, Liao J, Young M. Baranov P, et al. Among authors: lin h. J Ocul Pharmacol Ther. 2017 Jun;33(5):412-422. doi: 10.1089/jop.2016.0121. Epub 2017 Apr 25. J Ocul Pharmacol Ther. 2017. PMID: 28441076 Free PMC article.

4

Novel K_V7 ion channel openers for the treatment of epilepsy and implications for detrusor tissue contraction.

Seefeld MA, Lin H, Holenz J, Downie D, Donovan B, Fu T, Pasikanti K, Zhen W, Cato M, Chaudhary KW, Brady P, Bakshi T, Morrow D, Rajagopal S, Samanta SK, Madhyastha N, Kuppusamy BM, Dougherty RW, Bhamidipati R, Mohd Z, Higgins GA, Chapman M, Rouget C, Lluel P, Matsuoka Y. Seefeld MA, et al. Among authors: lin h. Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3793-3797. doi: 10.1016/j.bmcl.2018.09.036. Epub 2018 Sep 29. Bioorg Med Chem Lett. 2018. PMID: 30327146

5

Synthesis and structure-activity relationships of imidazo[1,2-a]pyrimidin-5(1H)-ones as a novel series of beta isoform selective phosphatidylinositol 3-kinase inhibitors.

Lin H, Erhard K, Hardwicke MA, Luengo JI, Mack JF, McSurdy-Freed J, Plant R, Raha K, Rominger CM, Sanchez RM, Schaber MD, Schulz MJ, Spengler MD, Tedesco R, Xie R, Zeng JJ, Rivero RA. Lin H, et al. Bioorg Med Chem Lett. 2012 Mar 15;22(6):2230-4. doi: 10.1016/j.bmcl.2012.01.092. Epub 2012 Feb 4. Bioorg Med Chem Lett. 2012. PMID: 22361133

6

2,3,5-Trisubstituted pyridines as selective AKT inhibitors. Part II: Improved drug-like properties and kinase selectivity from azaindazoles.

Lin H, Yamashita DS, Zeng J, Xie R, Verma S, Luengo JI, Rhodes N, Zhang S, Robell KA, Choudhry AE, Lai Z, Kumar R, Minthorn EA, Brown KK, Heerding DA. Lin H, et al. Bioorg Med Chem Lett. 2010 Jan 15;20(2):679-83. doi: 10.1016/j.bmcl.2009.11.060. Epub 2009 Nov 20. Bioorg Med Chem Lett. 2010. PMID: 20005102

7

Synthesis and structure-activity relationships of 1,2,4-triazolo[1,5-a]pyrimidin-7(3H)-ones as novel series of potent β isoform selective phosphatidylinositol 3-kinase inhibitors.

Sanchez RM, Erhard K, Hardwicke MA, Lin H, McSurdy-Freed J, Plant R, Raha K, Rominger CM, Schaber MD, Spengler MD, Moore ML, Yu H, Luengo JI, Tedesco R, Rivero RA. Sanchez RM, et al. Among authors: lin h. Bioorg Med Chem Lett. 2012 May 1;22(9):3198-202. doi: 10.1016/j.bmcl.2012.03.039. Epub 2012 Mar 16. Bioorg Med Chem Lett. 2012. PMID: 22475557

8

Discovery of a novel 2,3,11,11a-tetrahydro-1H-pyrazino[1,2-b]isoquinoline-1,4(6H)-dione series promoting neurogenesis of human neural progenitor cells.

Lin H, Fang H, Wang J, Meng Q, Dai X, Wu S, Luo J, Pu D, Chen L, Minick D, Arai K, Mandeville ET, Lo E, Holder JC, Chuang TT, Zhao J. Lin H, et al. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3748-53. doi: 10.1016/j.bmcl.2015.05.084. Epub 2015 Jun 11. Bioorg Med Chem Lett. 2015. PMID: 26142946

9

BET bromodomain inhibition promotes neurogenesis while inhibiting gliogenesis in neural progenitor cells.

Li J, Ma J, Meng G, Lin H, Wu S, Wang J, Luo J, Xu X, Tough D, Lindon M, Rioja I, Zhao J, Mei H, Prinjha R, Zhong Z. Li J, et al. Among authors: lin h. Stem Cell Res. 2016 Sep;17(2):212-221. doi: 10.1016/j.scr.2016.07.006. Epub 2016 Jul 20. Stem Cell Res. 2016. PMID: 27591477 Free article.

10

Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors.

Lin H, Zeng J, Xie R, Schulz MJ, Tedesco R, Qu J, Erhard KF, Mack JF, Raha K, Rendina AR, Szewczuk LM, Kratz PM, Jurewicz AJ, Cecconie T, Martens S, McDevitt PJ, Martin JD, Chen SB, Jiang Y, Nickels L, Schwartz BJ, Smallwood A, Zhao B, Campobasso N, Qian Y, Briand J, Rominger CM, Oleykowski C, Hardwicke MA, Luengo JI. Lin H, et al. ACS Med Chem Lett. 2015 Dec 28;7(3):217-22. doi: 10.1021/acsmedchemlett.5b00214. eCollection 2016 Mar 10. ACS Med Chem Lett. 2015. PMID: 26985301 Free PMC article.

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