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Absorption, Metabolism, and Excretion of [14C]-Tolebrutinib After Oral Administration in Humans, Contribution of the Metabolites to Pharmacological Activity.
Nicolas O, Moliner P, Soubayrol P, Vitse O, Roy S, Cabanis MJ, Turner T, Klieber S, Muccio S, Arabeyre C, Brun P. Nicolas O, et al. Among authors: arabeyre c. Clin Drug Investig. 2023 Aug;43(8):653-665. doi: 10.1007/s40261-023-01296-1. Epub 2023 Aug 29. Clin Drug Investig. 2023. PMID: 37642857 Free PMC article.
Mechanistic investigations of the liver toxicity of the free fatty acid receptor 1 agonist fasiglifam (TAK875) and its primary metabolites.
Ackerson T, Amberg A, Atzrodt J, Arabeyre C, Defossa E, Dorau M, Dudda A, Dwyer J, Holla W, Kissner T, Kohlmann M, Kürzel U, Pánczél J, Rajanna S, Riedel J, Schmidt F, Wäse K, Weitz D, Derdau V. Ackerson T, et al. Among authors: arabeyre c. J Biochem Mol Toxicol. 2019 Aug;33(8):e22345. doi: 10.1002/jbt.22345. Epub 2019 May 8. J Biochem Mol Toxicol. 2019. PMID: 31066974
Effect of deuteration on the metabolism and clearance of some pharmacologically active compounds--synthesis and in vitro metabolism of deuterated derivatives of dronedadrone.
Schofield J, Brasseur D, de Bruin B, Vassal T, Klieber S, Arabeyre C, Bourrié M, Sadoun F, Fabre G. Schofield J, et al. Among authors: arabeyre c. J Labelled Comp Radiopharm. 2013 Jul-Aug;56(9-10):504-12. doi: 10.1002/jlcr.3090. Epub 2013 Sep 4. J Labelled Comp Radiopharm. 2013. PMID: 24285529