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Liver adapts mitochondrial function to insulin resistant and diabetic states in mice.
Franko A, von Kleist-Retzow JC, Neschen S, Wu M, Schommers P, Böse M, Kunze A, Hartmann U, Sanchez-Lasheras C, Stoehr O, Huntgeburth M, Brodesser S, Irmler M, Beckers J, de Angelis MH, Paulsson M, Schubert M, Wiesner RJ. Franko A, et al. Among authors: wiesner rj. J Hepatol. 2014 Apr;60(4):816-23. doi: 10.1016/j.jhep.2013.11.020. Epub 2013 Nov 28. J Hepatol. 2014. PMID: 24291365
A new mechanism for mtDNA pathogenesis: impairment of post-transcriptional maturation leads to severe depletion of mitochondrial tRNASer(UCN) caused by T7512C and G7497A point mutations.
Möllers M, Maniura-Weber K, Kiseljakovic E, Bust M, Hayrapetyan A, Jaksch M, Helm M, Wiesner RJ, von Kleist-Retzow JC. Möllers M, et al. Among authors: wiesner rj. Nucleic Acids Res. 2005 Sep 30;33(17):5647-58. doi: 10.1093/nar/gki876. Print 2005. Nucleic Acids Res. 2005. PMID: 16199753 Free PMC article.
Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice.
Thierbach R, Schulz TJ, Isken F, Voigt A, Mietzner B, Drewes G, von Kleist-Retzow JC, Wiesner RJ, Magnuson MA, Puccio H, Pfeiffer AF, Steinberg P, Ristow M. Thierbach R, et al. Among authors: wiesner rj. Hum Mol Genet. 2005 Dec 15;14(24):3857-64. doi: 10.1093/hmg/ddi410. Epub 2005 Nov 8. Hum Mol Genet. 2005. PMID: 16278235
Impaired mitochondrial Ca2+ homeostasis in respiratory chain-deficient cells but efficient compensation of energetic disadvantage by enhanced anaerobic glycolysis due to low ATP steady state levels.
von Kleist-Retzow JC, Hornig-Do HT, Schauen M, Eckertz S, Dinh TA, Stassen F, Lottmann N, Bust M, Galunska B, Wielckens K, Hein W, Beuth J, Braun JM, Fischer JH, Ganitkevich VY, Maniura-Weber K, Wiesner RJ. von Kleist-Retzow JC, et al. Among authors: wiesner rj. Exp Cell Res. 2007 Aug 15;313(14):3076-89. doi: 10.1016/j.yexcr.2007.04.015. Epub 2007 Apr 19. Exp Cell Res. 2007. PMID: 17509565
117 results