Martens C - Search Results

1

Protonation drives the conformational switch in the multidrug transporter LmrP.

Masureel M, Martens C, Stein RA, Mishra S, Ruysschaert JM, Mchaourab HS, Govaerts C. Masureel M, et al. Among authors: martens c. Nat Chem Biol. 2014 Feb;10(2):149-55. doi: 10.1038/nchembio.1408. Epub 2013 Dec 8. Nat Chem Biol. 2014. PMID: 24316739 Free PMC article.

2

Lipids modulate the conformational dynamics of a secondary multidrug transporter.

Martens C, Stein RA, Masureel M, Roth A, Mishra S, Dawaliby R, Konijnenberg A, Sobott F, Govaerts C, Mchaourab HS. Martens C, et al. Nat Struct Mol Biol. 2016 Aug;23(8):744-51. doi: 10.1038/nsmb.3262. Epub 2016 Jul 11. Nat Struct Mol Biol. 2016. PMID: 27399258 Free PMC article.

3

An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity.

Debruycker V, Hutchin A, Masureel M, Ficici E, Martens C, Legrand P, Stein RA, Mchaourab HS, Faraldo-Gómez JD, Remaut H, Govaerts C. Debruycker V, et al. Among authors: martens c. Nat Struct Mol Biol. 2020 Sep;27(9):829-835. doi: 10.1038/s41594-020-0464-y. Epub 2020 Jul 27. Nat Struct Mol Biol. 2020. PMID: 32719456 Free PMC article.

4

Hydrogen-deuterium exchange mass spectrometry captures distinct dynamics upon substrate and inhibitor binding to a transporter.

Jia R, Martens C, Shekhar M, Pant S, Pellowe GA, Lau AM, Findlay HE, Harris NJ, Tajkhorshid E, Booth PJ, Politis A. Jia R, et al. Among authors: martens c. Nat Commun. 2020 Dec 2;11(1):6162. doi: 10.1038/s41467-020-20032-3. Nat Commun. 2020. PMID: 33268777 Free PMC article.

5

A topological switch in CFTR modulates channel activity and sensitivity to unfolding.

Scholl D, Sigoillot M, Overtus M, Martinez RC, Martens C, Wang Y, Pardon E, Laeremans T, Garcia-Pino A, Steyaert J, Sheppard DN, Hendrix J, Govaerts C. Scholl D, et al. Among authors: martens c. Nat Chem Biol. 2021 Sep;17(9):989-997. doi: 10.1038/s41589-021-00844-0. Epub 2021 Aug 2. Nat Chem Biol. 2021. PMID: 34341587

6

Direct protein-lipid interactions shape the conformational landscape of secondary transporters.

Martens C, Shekhar M, Borysik AJ, Lau AM, Reading E, Tajkhorshid E, Booth PJ, Politis A. Martens C, et al. Nat Commun. 2018 Oct 8;9(1):4151. doi: 10.1038/s41467-018-06704-1. Nat Commun. 2018. PMID: 30297844 Free PMC article.

7

Integrating hydrogen-deuterium exchange mass spectrometry with molecular dynamics simulations to probe lipid-modulated conformational changes in membrane proteins.

Martens C, Shekhar M, Lau AM, Tajkhorshid E, Politis A. Martens C, et al. Nat Protoc. 2019 Nov;14(11):3183-3204. doi: 10.1038/s41596-019-0219-6. Epub 2019 Oct 11. Nat Protoc. 2019. PMID: 31605097 Free PMC article.

8

Membrane Protein Production in Lactococcus lactis for Structural Studies.

Martens C. Martens C. Methods Mol Biol. 2020;2127:29-45. doi: 10.1007/978-1-0716-0373-4_3. Methods Mol Biol. 2020. PMID: 32112313

9

A glimpse into the molecular mechanism of integral membrane proteins through hydrogen-deuterium exchange mass spectrometry.

Martens C, Politis A. Martens C, et al. Protein Sci. 2020 Jun;29(6):1285-1301. doi: 10.1002/pro.3853. Epub 2020 Mar 25. Protein Sci. 2020. PMID: 32170968 Free PMC article. Review.

10

Assessing the Role of Lipids in the Molecular Mechanism of Membrane Proteins.

Jodaitis L, van Oene T, Martens C. Jodaitis L, et al. Among authors: martens c. Int J Mol Sci. 2021 Jul 6;22(14):7267. doi: 10.3390/ijms22147267. Int J Mol Sci. 2021. PMID: 34298884 Free PMC article. Review.

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