A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase.
Morgan HP, Walsh MJ, Blackburn EA, Wear MA, Boxer MB, Shen M, Veith H, McNae IW, Nowicki MW, Michels PA, Auld DS, Fothergill-Gilmore LA, Walkinshaw MD.
Morgan HP, et al.
Biochem J. 2012 Nov 15;448(1):67-72. doi: 10.1042/BJ20121014.
Biochem J. 2012.
PMID: 22906073
Free PMC article.