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On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts.
Iachettini S, Stevens MF, Frigerio M, Hummersone MG, Hutchinson I, Garner TP, Searle MS, Wilson DW, Munde M, Nanjunda R, D'Angelo C, Zizza P, Rizzo A, Cingolani C, De Cicco F, Porru M, D'Incalci M, Leonetti C, Biroccio A, Salvati E. Iachettini S, et al. Among authors: rizzo a. J Exp Clin Cancer Res. 2013 Sep 19;32(1):68. doi: 10.1186/1756-9966-32-68. J Exp Clin Cancer Res. 2013. PMID: 24330541 Free PMC article.
Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration.
Leonetti C, Amodei S, D'Angelo C, Rizzo A, Benassi B, Antonelli A, Elli R, Stevens MF, D'Incalci M, Zupi G, Biroccio A. Leonetti C, et al. Among authors: rizzo a. Mol Pharmacol. 2004 Nov;66(5):1138-46. doi: 10.1124/mol.104.001537. Epub 2004 Aug 10. Mol Pharmacol. 2004. PMID: 15304549
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect.
Salvati E, Leonetti C, Rizzo A, Scarsella M, Mottolese M, Galati R, Sperduti I, Stevens MF, D'Incalci M, Blasco M, Chiorino G, Bauwens S, Horard B, Gilson E, Stoppacciaro A, Zupi G, Biroccio A. Salvati E, et al. Among authors: rizzo a. J Clin Invest. 2007 Nov;117(11):3236-47. doi: 10.1172/JCI32461. J Clin Invest. 2007. PMID: 17932567 Free PMC article.
N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage.
Casagrande V, Salvati E, Alvino A, Bianco A, Ciammaichella A, D'Angelo C, Ginnari-Satriani L, Serrilli AM, Iachettini S, Leonetti C, Neidle S, Ortaggi G, Porru M, Rizzo A, Franceschin M, Biroccio A. Casagrande V, et al. Among authors: rizzo a. J Med Chem. 2011 Mar 10;54(5):1140-56. doi: 10.1021/jm1013665. Epub 2011 Jan 31. J Med Chem. 2011. PMID: 21280624
DNA damage persistence as determinant of tumor sensitivity to the combination of Topo I inhibitors and telomere-targeting agents.
Biroccio A, Porru M, Rizzo A, Salvati E, D'Angelo C, Orlandi A, Passeri D, Franceschin M, Stevens MF, Gilson E, Beretta G, Zupi G, Pisano C, Zunino F, Leonetti C. Biroccio A, et al. Among authors: rizzo a. Clin Cancer Res. 2011 Apr 15;17(8):2227-36. doi: 10.1158/1078-0432.CCR-10-3033. Epub 2011 Feb 25. Clin Cancer Res. 2011. PMID: 21355072
1,978 results