Freeman GJ - Search Results

1

Differential impact of PD-1 and/or interleukin-10 blockade on HIV-1-specific CD4 T cell and antigen-presenting cell functions.

Porichis F, Hart MG, Zupkosky J, Barblu L, Kwon DS, McMullen A, Brennan T, Ahmed R, Freeman GJ, Kavanagh DG, Kaufmann DE. Porichis F, et al. Among authors: freeman gj. J Virol. 2014 Mar;88(5):2508-18. doi: 10.1128/JVI.02034-13. Epub 2013 Dec 18. J Virol. 2014. PMID: 24352453 Free PMC article.

2

PD-L2 is a second ligand for PD-1 and inhibits T cell activation.

Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long AJ, Brown JA, Nunes R, Greenfield EA, Bourque K, Boussiotis VA, Carter LL, Carreno BM, Malenkovich N, Nishimura H, Okazaki T, Honjo T, Sharpe AH, Freeman GJ. Latchman Y, et al. Among authors: freeman gj. Nat Immunol. 2001 Mar;2(3):261-8. doi: 10.1038/85330. Nat Immunol. 2001. PMID: 11224527

3

Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production.

Brown JA, Dorfman DM, Ma FR, Sullivan EL, Munoz O, Wood CR, Greenfield EA, Freeman GJ. Brown JA, et al. Among authors: freeman gj. J Immunol. 2003 Feb 1;170(3):1257-66. doi: 10.4049/jimmunol.170.3.1257. J Immunol. 2003. PMID: 12538684

4

Endothelial expression of PD-L1 and PD-L2 down-regulates CD8+ T cell activation and cytolysis.

Rodig N, Ryan T, Allen JA, Pang H, Grabie N, Chernova T, Greenfield EA, Liang SC, Sharpe AH, Lichtman AH, Freeman GJ. Rodig N, et al. Among authors: freeman gj. Eur J Immunol. 2003 Nov;33(11):3117-26. doi: 10.1002/eji.200324270. Eur J Immunol. 2003. PMID: 14579280 Free article.

5

PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells.

Latchman YE, Liang SC, Wu Y, Chernova T, Sobel RA, Klemm M, Kuchroo VK, Freeman GJ, Sharpe AH. Latchman YE, et al. Among authors: freeman gj. Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10691-6. doi: 10.1073/pnas.0307252101. Epub 2004 Jul 12. Proc Natl Acad Sci U S A. 2004. PMID: 15249675 Free PMC article.

6

Restoring function in exhausted CD8 T cells during chronic viral infection.

Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, Sharpe AH, Freeman GJ, Ahmed R. Barber DL, et al. Among authors: freeman gj. Nature. 2006 Feb 9;439(7077):682-7. doi: 10.1038/nature04444. Epub 2005 Dec 28. Nature. 2006. PMID: 16382236

7

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression.

Day CL, Kaufmann DE, Kiepiela P, Brown JA, Moodley ES, Reddy S, Mackey EW, Miller JD, Leslie AJ, DePierres C, Mncube Z, Duraiswamy J, Zhu B, Eichbaum Q, Altfeld M, Wherry EJ, Coovadia HM, Goulder PJ, Klenerman P, Ahmed R, Freeman GJ, Walker BD. Day CL, et al. Among authors: freeman gj. Nature. 2006 Sep 21;443(7109):350-4. doi: 10.1038/nature05115. Epub 2006 Aug 20. Nature. 2006. PMID: 16921384

8

Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade.

Freeman GJ, Wherry EJ, Ahmed R, Sharpe AH. Freeman GJ, et al. J Exp Med. 2006 Oct 2;203(10):2223-7. doi: 10.1084/jem.20061800. Epub 2006 Sep 25. J Exp Med. 2006. PMID: 17000870 Free PMC article. Review.

9

Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression.

Radziewicz H, Ibegbu CC, Fernandez ML, Workowski KA, Obideen K, Wehbi M, Hanson HL, Steinberg JP, Masopust D, Wherry EJ, Altman JD, Rouse BT, Freeman GJ, Ahmed R, Grakoui A. Radziewicz H, et al. Among authors: freeman gj. J Virol. 2007 Mar;81(6):2545-53. doi: 10.1128/JVI.02021-06. Epub 2006 Dec 20. J Virol. 2007. PMID: 17182670 Free PMC article.

10

The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection.

Sharpe AH, Wherry EJ, Ahmed R, Freeman GJ. Sharpe AH, et al. Among authors: freeman gj. Nat Immunol. 2007 Mar;8(3):239-45. doi: 10.1038/ni1443. Nat Immunol. 2007. PMID: 17304234 Review.

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