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Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection.
Doitsh G, Galloway NL, Geng X, Yang Z, Monroe KM, Zepeda O, Hunt PW, Hatano H, Sowinski S, Muñoz-Arias I, Greene WC. Doitsh G, et al. Among authors: yang z. Nature. 2014 Jan 23;505(7484):509-14. doi: 10.1038/nature12940. Nature. 2014. PMID: 24356306 Free PMC article.
Small molecule inhibits KCNQ channels with a non-blocking mechanism.
Li J, Yang Z, Zhang S, Ye Y, He J, Zhang Y, Han H, Kong W, Liu J, Min Y, Shen J, Mei L, Chen Z, Hou P, Guo J, Zhang Q, Yang H. Li J, et al. Among authors: yang z. Nat Chem Biol. 2025 Jan 15. doi: 10.1038/s41589-024-01834-8. Online ahead of print. Nat Chem Biol. 2025. PMID: 39814994
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