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Selective acetyl- and butyrylcholinesterase inhibitors reduce amyloid-β ex vivo activation of peripheral chemo-cytokines from Alzheimer's disease subjects: exploring the cholinergic anti-inflammatory pathway.
Reale M, Di Nicola M, Velluto L, D'Angelo C, Costantini E, Lahiri DK, Kamal MA, Yu QS, Greig NH. Reale M, et al. Among authors: yu qs. Curr Alzheimer Res. 2014;11(6):608-22. doi: 10.2174/1567205010666131212113218. Curr Alzheimer Res. 2014. PMID: 24359497 Free PMC article.
Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent.
Greig NH, Utsuki T, Ingram DK, Wang Y, Pepeu G, Scali C, Yu QS, Mamczarz J, Holloway HW, Giordano T, Chen D, Furukawa K, Sambamurti K, Brossi A, Lahiri DK. Greig NH, et al. Among authors: yu qs. Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17213-8. doi: 10.1073/pnas.0508575102. Epub 2005 Nov 7. Proc Natl Acad Sci U S A. 2005. PMID: 16275899 Free PMC article.
Synthesis of the Alzheimer drug Posiphen into its primary metabolic products (+)-N1-norPosiphen, (+)-N8-norPosiphen and (+)-N1, N8-bisnorPosiphen, their inhibition of amyloid precursor protein, α-Synuclein synthesis, interleukin-1β release, and cholinergic action.
Yu QS, Reale M, Kamal MA, Holloway HW, Luo W, Sambamurti K, Ray B, Lahiri DK, Rogers JT, Greig NH. Yu QS, et al. Antiinflamm Antiallergy Agents Med Chem. 2013;12(2):117-28. doi: 10.2174/1871523011312020003. Antiinflamm Antiallergy Agents Med Chem. 2013. PMID: 23360256 Free PMC article.
130 results