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Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE*3Leiden.CETP mice--a translational model for atherosclerosis.
Gierman LM, Kühnast S, Koudijs A, Pieterman EJ, Kloppenburg M, van Osch GJ, Stojanovic-Susulic V, Huizinga TW, Princen HM, Zuurmond AM. Gierman LM, et al. Among authors: pieterman ej. Ann Rheum Dis. 2014 May;73(5):921-7. doi: 10.1136/annrheumdis-2013-203248. Epub 2013 Apr 26. Ann Rheum Dis. 2014. PMID: 23625977
Variable cartilage degradation in mice with diet-induced metabolic dysfunction: food for thought.
Kozijn AE, Gierman LM, van der Ham F, Mulder P, Morrison MC, Kühnast S, van der Heijden RA, Stavro PM, van Koppen A, Pieterman EJ, van den Hoek AM, Kleemann R, Princen HMG, Mastbergen SC, Lafeber FPJG, Zuurmond AM, Bobeldijk I, Weinans H, Stoop R. Kozijn AE, et al. Among authors: pieterman ej. Osteoarthritis Cartilage. 2018 Jan;26(1):95-107. doi: 10.1016/j.joca.2017.10.010. Epub 2017 Oct 24. Osteoarthritis Cartilage. 2018. PMID: 29074298 Free article.
Inhibition of macrophage proliferation dominates plaque regression in response to cholesterol lowering.
Härdtner C, Kornemann J, Krebs K, Ehlert CA, Jander A, Zou J, Starz C, Rauterberg S, Sharipova D, Dufner B, Hoppe N, Dederichs TS, Willecke F, Stachon P, Heidt T, Wolf D, von Zur Mühlen C, Madl J, Kohl P, Kaeser R, Boettler T, Pieterman EJ, Princen HMG, Ho-Tin-Noé B, Swirski FK, Robbins CS, Bode C, Zirlik A, Hilgendorf I. Härdtner C, et al. Among authors: pieterman ej. Basic Res Cardiol. 2020 Dec 9;115(6):78. doi: 10.1007/s00395-020-00838-4. Basic Res Cardiol. 2020. PMID: 33296022 Free PMC article.
Novel high-intensive cholesterol-lowering therapies do not ameliorate knee OA development in humanized dyslipidemic mice.
van Gemert Y, Kozijn AE, Pouwer MG, Kruisbergen NNL, van den Bosch MHJ, Blom AB, Pieterman EJ, Weinans H, Stoop R, Princen HMG, van Lent PLEM. van Gemert Y, et al. Among authors: pieterman ej. Osteoarthritis Cartilage. 2021 Sep;29(9):1314-1323. doi: 10.1016/j.joca.2021.02.570. Epub 2021 Mar 12. Osteoarthritis Cartilage. 2021. PMID: 33722697 Free article.
IL-1β inhibition combined with cholesterol-lowering therapies decreases synovial lining thickness and spontaneous cartilage degeneration in a humanized dyslipidemia mouse model.
van Gemert Y, Kruisbergen NNL, Blom AB, van den Bosch MHJ, van der Kraan PM, Pieterman EJ, Princen HMG, van Lent PLEM. van Gemert Y, et al. Among authors: pieterman ej. Osteoarthritis Cartilage. 2023 Mar;31(3):340-350. doi: 10.1016/j.joca.2022.09.014. Epub 2022 Nov 25. Osteoarthritis Cartilage. 2023. PMID: 36442605 Free article.
Intensive cholesterol-lowering treatment reduces synovial inflammation during early collagenase-induced osteoarthritis, but not pathology at end-stage disease in female dyslipidemic E3L.CETP mice.
van Gemert Y, Blom AB, Di Ceglie I, Walgreen B, Helsen M, Sloetjes A, Vogl T, Roth J, Kruisbergen NNL, Pieterman EJ, Princen HMG, van der Kraan PM, van Lent PLEM, van den Bosch MHJ. van Gemert Y, et al. Among authors: pieterman ej. Osteoarthritis Cartilage. 2023 Jul;31(7):934-943. doi: 10.1016/j.joca.2023.01.577. Epub 2023 Mar 8. Osteoarthritis Cartilage. 2023. PMID: 36898656 Free article.
46 results