Roth A - Search Results

1

The application of 3D cell models to support drug safety assessment: opportunities & challenges.

Roth A, Singer T. Roth A, et al. Adv Drug Deliv Rev. 2014 Apr;69-70:179-89. doi: 10.1016/j.addr.2013.12.005. Epub 2013 Dec 27. Adv Drug Deliv Rev. 2014. PMID: 24378580 Review.

2

Gene expression-based in vivo and in vitro prediction of liver toxicity allows compound selection at an early stage of drug development.

Roth A, Boess F, Landes C, Steiner G, Freichel C, Plancher JM, Raab S, de Vera Mudry C, Weiser T, Suter L. Roth A, et al. J Biochem Mol Toxicol. 2011 May-Jun;25(3):183-94. doi: 10.1002/jbt.20375. Epub 2010 Nov 12. J Biochem Mol Toxicol. 2011. PMID: 21671310

3

Monitoring Cyp2b10 mRNA expression at cessation of 2-year carcinogenesis bioassay in mouse liver provides evidence for a carcinogenic mechanism devoid of human relevance: the dalcetrapib experience.

Hoflack JC, Mueller L, Fowler S, Braendli-Baiocco A, Flint N, Kuhlmann O, Singer T, Roth A. Hoflack JC, et al. Among authors: roth a. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):355-65. doi: 10.1016/j.taap.2012.01.014. Epub 2012 Jan 28. Toxicol Appl Pharmacol. 2012. PMID: 22293087

4

A label-free, impedance-based real time assay to identify drug-induced toxicities and differentiate cytostatic from cytotoxic effects.

Kustermann S, Boess F, Buness A, Schmitz M, Watzele M, Weiser T, Singer T, Suter L, Roth A. Kustermann S, et al. Among authors: roth a. Toxicol In Vitro. 2013 Aug;27(5):1589-95. doi: 10.1016/j.tiv.2012.08.019. Epub 2012 Aug 28. Toxicol In Vitro. 2013. PMID: 22954529

5

A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity.

Kostadinova R, Boess F, Applegate D, Suter L, Weiser T, Singer T, Naughton B, Roth A. Kostadinova R, et al. Among authors: roth a. Toxicol Appl Pharmacol. 2013 Apr 1;268(1):1-16. doi: 10.1016/j.taap.2013.01.012. Epub 2013 Jan 23. Toxicol Appl Pharmacol. 2013. PMID: 23352505

6

Effect of GLP1R agonists taspoglutide and liraglutide on primary thyroid C-cells from rodent and man.

Boess F, Bertinetti-Lapatki C, Zoffmann S, George C, Pfister T, Roth A, Lee SM, Thasler WE, Singer T, Suter L. Boess F, et al. Among authors: roth a. J Mol Endocrinol. 2013 Apr 12;50(3):325-36. doi: 10.1530/JME-12-0186. Print 2013 Jun. J Mol Endocrinol. 2013. PMID: 23463748

7

A real-time impedance-based screening assay for drug-induced vascular leakage.

Kustermann S, Manigold T, Ploix C, Skubatz M, Heckel T, Hinton H, Weiser T, Singer T, Suter L, Roth A. Kustermann S, et al. Among authors: roth a. Toxicol Sci. 2014 Apr;138(2):333-43. doi: 10.1093/toxsci/kft336. Epub 2014 Jan 2. Toxicol Sci. 2014. PMID: 24385420

8

Stem cell-derived systems in toxicology assessment.

Suter-Dick L, Alves PM, Blaauboer BJ, Bremm KD, Brito C, Coecke S, Flick B, Fowler P, Hescheler J, Ingelman-Sundberg M, Jennings P, Kelm JM, Manou I, Mistry P, Moretto A, Roth A, Stedman D, van de Water B, Beilmann M. Suter-Dick L, et al. Among authors: roth a. Stem Cells Dev. 2015 Jun 1;24(11):1284-96. doi: 10.1089/scd.2014.0540. Epub 2015 Mar 31. Stem Cells Dev. 2015. PMID: 25675366 Review.

9

Minimizing DILI risk in drug discovery - A screening tool for drug candidates.

Schadt S, Simon S, Kustermann S, Boess F, McGinnis C, Brink A, Lieven R, Fowler S, Youdim K, Ullah M, Marschmann M, Zihlmann C, Siegrist YM, Cascais AC, Di Lenarda E, Durr E, Schaub N, Ang X, Starke V, Singer T, Alvarez-Sanchez R, Roth AB, Schuler F, Funk C. Schadt S, et al. Among authors: roth ab. Toxicol In Vitro. 2015 Dec 25;30(1 Pt B):429-37. doi: 10.1016/j.tiv.2015.09.019. Epub 2015 Sep 25. Toxicol In Vitro. 2015. PMID: 26407524

10

Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro.

Nguyen DG, Funk J, Robbins JB, Crogan-Grundy C, Presnell SC, Singer T, Roth AB. Nguyen DG, et al. PLoS One. 2016 Jul 7;11(7):e0158674. doi: 10.1371/journal.pone.0158674. eCollection 2016. PLoS One. 2016. PMID: 27387377 Free PMC article.

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