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Page 1
An ingestible self-orienting system for oral delivery of macromolecules.
Abramson A, Caffarel-Salvador E, Khang M, Dellal D, Silverstein D, Gao Y, Frederiksen MR, Vegge A, Hubálek F, Water JJ, Friderichsen AV, Fels J, Kirk RK, Cleveland C, Collins J, Tamang S, Hayward A, Landh T, Buckley ST, Roxhed N, Rahbek U, Langer R, Traverso G. Abramson A, et al. Among authors: hubalek f. Science. 2019 Feb 8;363(6427):611-615. doi: 10.1126/science.aau2277. Science. 2019. PMID: 30733413 Free PMC article.
A microneedle platform for buccal macromolecule delivery.
Caffarel-Salvador E, Kim S, Soares V, Tian RY, Stern SR, Minahan D, Yona R, Lu X, Zakaria FR, Collins J, Wainer J, Wong J, McManus R, Tamang S, McDonnell S, Ishida K, Hayward A, Liu X, Hubálek F, Fels J, Vegge A, Frederiksen MR, Rahbek U, Yoshitake T, Fujimoto J, Roxhed N, Langer R, Traverso G. Caffarel-Salvador E, et al. Among authors: hubalek f. Sci Adv. 2021 Jan 22;7(4):eabe2620. doi: 10.1126/sciadv.abe2620. Print 2021 Jan. Sci Adv. 2021. PMID: 33523951 Free PMC article.
Oral delivery of systemic monoclonal antibodies, peptides and small molecules using gastric auto-injectors.
Abramson A, Frederiksen MR, Vegge A, Jensen B, Poulsen M, Mouridsen B, Jespersen MO, Kirk RK, Windum J, Hubálek F, Water JJ, Fels J, Gunnarsson SB, Bohr A, Straarup EM, Ley MWH, Lu X, Wainer J, Collins J, Tamang S, Ishida K, Hayward A, Herskind P, Buckley ST, Roxhed N, Langer R, Rahbek U, Traverso G. Abramson A, et al. Among authors: hubalek f. Nat Biotechnol. 2022 Jan;40(1):103-109. doi: 10.1038/s41587-021-01024-0. Epub 2021 Aug 30. Nat Biotechnol. 2022. PMID: 34462588 Free PMC article.
Structural characterization of insulin NPH formulations.
Norrman M, Hubálek F, Schluckebier G. Norrman M, et al. Among authors: hubalek f. Eur J Pharm Sci. 2007 Apr;30(5):414-23. doi: 10.1016/j.ejps.2007.01.003. Epub 2007 Jan 20. Eur J Pharm Sci. 2007. PMID: 17339105
Backbone cyclic insulin.
Andersen AS, Palmqvist E, Bang S, Shaw AC, Hubalek F, Ribel U, Hoeg-Jensen T. Andersen AS, et al. Among authors: hubalek f. J Pept Sci. 2010 Sep;16(9):473-9. doi: 10.1002/psc.1264. J Pept Sci. 2010. PMID: 20641002
Molecular engineering of safe and efficacious oral basal insulin.
Hubálek F, Refsgaard HHF, Gram-Nielsen S, Madsen P, Nishimura E, Münzel M, Brand CL, Stidsen CE, Claussen CH, Wulff EM, Pridal L, Ribel U, Kildegaard J, Porsgaard T, Johansson E, Steensgaard DB, Hovgaard L, Glendorf T, Hansen BF, Jensen MK, Nielsen PK, Ludvigsen S, Rugh S, Garibay PW, Moore MC, Cherrington AD, Kjeldsen T. Hubálek F, et al. Nat Commun. 2020 Jul 27;11(1):3746. doi: 10.1038/s41467-020-17487-9. Nat Commun. 2020. PMID: 32719315 Free PMC article.
Engineering of Orally Available, Ultralong-Acting Insulin Analogues: Discovery of OI338 and OI320.
Kjeldsen TB, Hubálek F, Tagmose TM, Pridal L, Refsgaard HHF, Porsgaard T, Gram-Nielsen S, Hovgaard L, Valore H, Münzel M, Hjørringgaard CU, Jeppesen CB, Manfè V, Hoeg-Jensen T, Ludvigsen S, Nielsen PK, Lautrup-Larsen I, Stidsen CE, Wulff EM, Garibay PW, Kodra JT, Nishimura E, Madsen P. Kjeldsen TB, et al. Among authors: hubalek f. J Med Chem. 2021 Jan 14;64(1):616-628. doi: 10.1021/acs.jmedchem.0c01576. Epub 2020 Dec 28. J Med Chem. 2021. PMID: 33356257
60 results