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An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients.
Spina CA, Anderson J, Archin NM, Bosque A, Chan J, Famiglietti M, Greene WC, Kashuba A, Lewin SR, Margolis DM, Mau M, Ruelas D, Saleh S, Shirakawa K, Siliciano RF, Singhania A, Soto PC, Terry VH, Verdin E, Woelk C, Wooden S, Xing S, Planelles V. Spina CA, et al. Among authors: siliciano rf. PLoS Pathog. 2013;9(12):e1003834. doi: 10.1371/journal.ppat.1003834. Epub 2013 Dec 26. PLoS Pathog. 2013. PMID: 24385908 Free PMC article.
Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy.
Finzi D, Blankson J, Siliciano JD, Margolick JB, Chadwick K, Pierson T, Smith K, Lisziewicz J, Lori F, Flexner C, Quinn TC, Chaisson RE, Rosenberg E, Walker B, Gange S, Gallant J, Siliciano RF. Finzi D, et al. Among authors: siliciano jd, siliciano rf. Nat Med. 1999 May;5(5):512-7. doi: 10.1038/8394. Nat Med. 1999. PMID: 10229227
Persistence of wild-type virus and lack of temporal structure in the latent reservoir for human immunodeficiency virus type 1 in pediatric patients with extensive antiretroviral exposure.
Ruff CT, Ray SC, Kwon P, Zinn R, Pendleton A, Hutton N, Ashworth R, Gange S, Quinn TC, Siliciano RF, Persaud D. Ruff CT, et al. Among authors: siliciano rf. J Virol. 2002 Sep;76(18):9481-92. doi: 10.1128/jvi.76.18.9481-9492.2002. J Virol. 2002. PMID: 12186930 Free PMC article.
Resting CD4+ T lymphocytes but not thymocytes provide a latent viral reservoir in a simian immunodeficiency virus-Macaca nemestrina model of human immunodeficiency virus type 1-infected patients on highly active antiretroviral therapy.
Shen A, Zink MC, Mankowski JL, Chadwick K, Margolick JB, Carruth LM, Li M, Clements JE, Siliciano RF. Shen A, et al. Among authors: siliciano rf. J Virol. 2003 Apr;77(8):4938-49. doi: 10.1128/jvi.77.8.4938-4949.2003. J Virol. 2003. PMID: 12663799 Free PMC article.
356 results