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Structure-activity relationships of diamine inhibitors of cytochrome P450 (CYP) 3A as novel pharmacoenhancers. Part II: P2/P3 region and discovery of cobicistat (GS-9350).
Xu L, Liu H, Hong A, Vivian R, Murray BP, Callebaut C, Choi YC, Lee MS, Chau J, Tsai LK, Stray KM, Strickley RG, Wang J, Tong L, Swaminathan S, Rhodes GR, Desai MC. Xu L, et al. Bioorg Med Chem Lett. 2014 Feb 1;24(3):995-9. doi: 10.1016/j.bmcl.2013.12.057. Epub 2013 Dec 21. Bioorg Med Chem Lett. 2014. PMID: 24412072
Pharmacokinetic enhancers for HIV drugs.
Xu L, Desai MC. Xu L, et al. Curr Opin Investig Drugs. 2009 Aug;10(8):775-86. Curr Opin Investig Drugs. 2009. PMID: 19649922 Review.
N1-Alkyl pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Mitchell ML, Son JC, Guo H, Im YA, Cho EJ, Wang J, Hayes J, Wang M, Paul A, Lansdon EB, Chen JM, Graupe D, Rhodes G, He GX, Geleziunas R, Xu L, Kim CU. Mitchell ML, et al. Among authors: xu l. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1589-92. doi: 10.1016/j.bmcl.2010.01.085. Epub 2010 Jan 21. Bioorg Med Chem Lett. 2010. PMID: 20138513
In vitro characterization of GS-8374, a novel phosphonate-containing inhibitor of HIV-1 protease with a favorable resistance profile.
Callebaut C, Stray K, Tsai L, Williams M, Yang ZY, Cannizzaro C, Leavitt SA, Liu X, Wang K, Murray BP, Mulato A, Hatada M, Priskich T, Parkin N, Swaminathan S, Lee W, He GX, Xu L, Cihlar T. Callebaut C, et al. Among authors: xu l. Antimicrob Agents Chemother. 2011 Apr;55(4):1366-76. doi: 10.1128/AAC.01183-10. Epub 2011 Jan 18. Antimicrob Agents Chemother. 2011. PMID: 21245449 Free PMC article.
SAR studies on dihydropyrimidinone antibiotics.
Xu L, Zhang L, Jones R, Bryant C, Boddeker N, Mabery E, Bahador G, Watson J, Clough J, Arimilli M, Gillette W, Colagiovanni D, Wang K, Gibbs C, Kim CU. Xu L, et al. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1670-4. doi: 10.1016/j.bmcl.2011.01.099. Epub 2011 Jan 31. Bioorg Med Chem Lett. 2011. PMID: 21324685
Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymerase.
Fenaux M, Eng S, Leavitt SA, Lee YJ, Mabery EM, Tian Y, Byun D, Canales E, Clarke MO, Doerffler E, Lazerwith SE, Lew W, Liu Q, Mertzman M, Morganelli P, Xu L, Ye H, Zhang J, Matles M, Murray BP, Mwangi J, Zhang J, Hashash A, Krawczyk SH, Bidgood AM, Appleby TC, Watkins WJ. Fenaux M, et al. Among authors: xu l. Antimicrob Agents Chemother. 2013 Feb;57(2):804-10. doi: 10.1128/AAC.02052-12. Epub 2012 Nov 26. Antimicrob Agents Chemother. 2013. PMID: 23183437 Free PMC article. Clinical Trial.
Synthesis and biological evaluation of phosphonate analogues of nevirapine.
Parrish J, Tong L, Wang M, Chen X, Lansdon EB, Cannizzaro C, Zheng X, Desai MC, Xu L. Parrish J, et al. Among authors: xu l. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1493-7. doi: 10.1016/j.bmcl.2012.12.049. Epub 2012 Dec 21. Bioorg Med Chem Lett. 2013. PMID: 23375792
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