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Structural analyses of 4-phosphate adaptor protein 2 yield mechanistic insights into sphingolipid recognition by the glycolipid transfer protein family.
Ochoa-Lizarralde B, Gao YG, Popov AN, Samygina VR, Zhai X, Mishra SK, Boldyrev IA, Molotkovsky JG, Simanshu DK, Patel DJ, Brown RE, Malinina L. Ochoa-Lizarralde B, et al. Among authors: simanshu dk. J Biol Chem. 2018 Oct 26;293(43):16709-16723. doi: 10.1074/jbc.RA117.000733. Epub 2018 Sep 11. J Biol Chem. 2018. PMID: 30206120 Free PMC article.
Structural determination and tryptophan fluorescence of heterokaryon incompatibility C2 protein (HET-C2), a fungal glycolipid transfer protein (GLTP), provide novel insights into glycolipid specificity and membrane interaction by the GLTP fold.
Kenoth R, Simanshu DK, Kamlekar RK, Pike HM, Molotkovsky JG, Benson LM, Bergen HR 3rd, Prendergast FG, Malinina L, Venyaminov SY, Patel DJ, Brown RE. Kenoth R, et al. Among authors: simanshu dk. J Biol Chem. 2010 Apr 23;285(17):13066-78. doi: 10.1074/jbc.M109.093203. Epub 2010 Feb 17. J Biol Chem. 2010. PMID: 20164530 Free PMC article.
The glycolipid transfer protein (GLTP) domain of phosphoinositol 4-phosphate adaptor protein-2 (FAPP2): structure drives preference for simple neutral glycosphingolipids.
Kamlekar RK, Simanshu DK, Gao YG, Kenoth R, Pike HM, Prendergast FG, Malinina L, Molotkovsky JG, Venyaminov SY, Patel DJ, Brown RE. Kamlekar RK, et al. Among authors: simanshu dk. Biochim Biophys Acta. 2013 Feb;1831(2):417-27. doi: 10.1016/j.bbalip.2012.10.010. Epub 2012 Nov 16. Biochim Biophys Acta. 2013. PMID: 23159414 Free PMC article.
Uridylation by TUT4 and TUT7 marks mRNA for degradation.
Lim J, Ha M, Chang H, Kwon SC, Simanshu DK, Patel DJ, Kim VN. Lim J, et al. Among authors: simanshu dk. Cell. 2014 Dec 4;159(6):1365-76. doi: 10.1016/j.cell.2014.10.055. Cell. 2014. PMID: 25480299 Free PMC article.
65 results