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IFN-γ-mediated reduction of large-conductance, Ca2+-activated, voltage-dependent K+ (BK) channel activity in airway epithelial cells leads to mucociliary dysfunction.
Manzanares D, Srinivasan M, Salathe ST, Ivonnet P, Baumlin N, Dennis JS, Conner GE, Salathe M. Manzanares D, et al. Among authors: dennis js. Am J Physiol Lung Cell Mol Physiol. 2014 Mar 1;306(5):L453-62. doi: 10.1152/ajplung.00247.2013. Epub 2014 Jan 10. Am J Physiol Lung Cell Mol Physiol. 2014. PMID: 24414257 Free PMC article.
Airway Surface Dehydration by Transforming Growth Factor β (TGF-β) in Cystic Fibrosis Is Due to Decreased Function of a Voltage-dependent Potassium Channel and Can Be Rescued by the Drug Pirfenidone.
Manzanares D, Krick S, Baumlin N, Dennis JS, Tyrrell J, Tarran R, Salathe M. Manzanares D, et al. Among authors: dennis js. J Biol Chem. 2015 Oct 16;290(42):25710-6. doi: 10.1074/jbc.M115.670885. Epub 2015 Sep 3. J Biol Chem. 2015. PMID: 26338706 Free PMC article.
Losartan Rescues Inflammation-related Mucociliary Dysfunction in Relevant Models of Cystic Fibrosis.
Kim MD, Baumlin N, Yoshida M, Polineni D, Salathe SF, David JK, Peloquin CA, Wanner A, Dennis JS, Sailland J, Whitney P, Horrigan FT, Sabater JR, Abraham WM, Salathe M. Kim MD, et al. Among authors: dennis js. Am J Respir Crit Care Med. 2020 Feb 1;201(3):313-324. doi: 10.1164/rccm.201905-0990OC. Am J Respir Crit Care Med. 2020. PMID: 31613648 Free PMC article.
The Effects of the Anti-aging Protein Klotho on Mucociliary Clearance.
Garth J, Easter M, Skylar Harris E, Sailland J, Kuenzi L, Chung S, Dennis JS, Baumlin N, Adewale AT, Rowe SM, King G, Faul C, Barnes JW, Salathe M, Krick S. Garth J, et al. Among authors: dennis js. Front Med (Lausanne). 2020 Jan 24;6:339. doi: 10.3389/fmed.2019.00339. eCollection 2019. Front Med (Lausanne). 2020. PMID: 32039219 Free PMC article.
48 results