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Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5).
Reddy MV, Akula B, Cosenza SC, Athuluridivakar S, Mallireddigari MR, Pallela VR, Billa VK, Subbaiah DR, Bharathi EV, Vasquez-Del Carpio R, Padgaonkar A, Baker SJ, Reddy EP. Reddy MV, et al. Among authors: baker sj. J Med Chem. 2014 Feb 13;57(3):578-99. doi: 10.1021/jm401073p. Epub 2014 Jan 24. J Med Chem. 2014. PMID: 24417566 Free PMC article.
Targeted inhibition of kinases in cancer therapy.
Baker SJ, Reddy EP. Baker SJ, et al. Mt Sinai J Med. 2010 Nov-Dec;77(6):573-86. doi: 10.1002/msj.20220. Mt Sinai J Med. 2010. PMID: 21105121 Free PMC article. Review.
Targeting protein kinase CK2 and CDK4/6 pathways with a multi-kinase inhibitor ON108110 suppresses pro-survival signaling and growth in mantle cell lymphoma and T-acute lymphoblastic leukemia.
Padgaonkar A, Rechkoblit O, Vasquez-Del Carpio R, Pallela V, Venkata Subbaiah D, Cosenza SC, Baker SJ, Ramana Reddy MV, Aggarwal A, Reddy EP. Padgaonkar A, et al. Among authors: baker sj. Oncotarget. 2018 Dec 28;9(102):37753-37765. doi: 10.18632/oncotarget.26514. eCollection 2018 Dec 28. Oncotarget. 2018. PMID: 30701029 Free PMC article.
A Contaminant Impurity, Not Rigosertib, Is a Tubulin Binding Agent.
Baker SJ, Cosenza SC, Athuluri-Divakar S, Reddy MVR, Vasquez-Del Carpio R, Jain R, Aggarwal AK, Reddy EP. Baker SJ, et al. Mol Cell. 2020 Jul 2;79(1):180-190.e4. doi: 10.1016/j.molcel.2020.05.024. Mol Cell. 2020. PMID: 32619468 Free PMC article.
Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease.
Sato K, Padgaonkar AA, Baker SJ, Cosenza SC, Rechkoblit O, Subbaiah DRCV, Domingo-Domenech J, Bartkowski A, Port ER, Aggarwal AK, Ramana Reddy MV, Irie HY, Reddy EP. Sato K, et al. Among authors: baker sj. Nat Commun. 2021 Aug 3;12(1):4671. doi: 10.1038/s41467-021-24878-z. Nat Commun. 2021. PMID: 34344863 Free PMC article.
420 results