Lin TH - Search Results

1

Application of physiologically based absorption modeling to formulation development of a low solubility, low permeability weak base: mechanistic investigation of food effect.

Zhang H, Xia B, Sheng J, Heimbach T, Lin TH, He H, Wang Y, Novick S, Comfort A. Zhang H, et al. Among authors: lin th. AAPS PharmSciTech. 2014 Apr;15(2):400-6. doi: 10.1208/s12249-014-0075-1. Epub 2014 Jan 17. AAPS PharmSciTech. 2014. PMID: 24435225 Free PMC article.

2

Case studies for practical food effect assessments across BCS/BDDCS class compounds using in silico, in vitro, and preclinical in vivo data.

Heimbach T, Xia B, Lin TH, He H. Heimbach T, et al. Among authors: lin th. AAPS J. 2013 Jan;15(1):143-58. doi: 10.1208/s12248-012-9419-5. Epub 2012 Nov 10. AAPS J. 2013. PMID: 23139017 Free PMC article.

3

Utility of physiologically based modeling and preclinical in vitro/in vivo data to mitigate positive food effect in a BCS class 2 compound.

Xia B, Heimbach T, Lin TH, Li S, Zhang H, Sheng J, He H. Xia B, et al. Among authors: lin th. AAPS PharmSciTech. 2013 Sep;14(3):1255-66. doi: 10.1208/s12249-013-0018-2. Epub 2013 Aug 17. AAPS PharmSciTech. 2013. PMID: 23955148 Free PMC article. Clinical Trial.

4

Novel physiologically based pharmacokinetic modeling of patupilone for human pharmacokinetic predictions.

Xia B, Heimbach T, Lin TH, He H, Wang Y, Tan E. Xia B, et al. Among authors: lin th. Cancer Chemother Pharmacol. 2012 Jun;69(6):1567-82. doi: 10.1007/s00280-012-1863-5. Epub 2012 Apr 11. Cancer Chemother Pharmacol. 2012. PMID: 22526410

5

Nilotinib preclinical pharmacokinetics and practical application toward clinical projections of oral absorption and systemic availability.

Xia B, Heimbach T, He H, Lin TH. Xia B, et al. Among authors: lin th. Biopharm Drug Dispos. 2012 Dec;33(9):536-49. doi: 10.1002/bdd.1821. Epub 2012 Nov 19. Biopharm Drug Dispos. 2012. PMID: 23097199

6

Evaluation of Drug-Drug Interaction Potential Between Sacubitril/Valsartan (LCZ696) and Statins Using a Physiologically Based Pharmacokinetic Model.

Lin W, Ji T, Einolf H, Ayalasomayajula S, Lin TH, Hanna I, Heimbach T, Breen C, Jarugula V, He H. Lin W, et al. Among authors: lin th. J Pharm Sci. 2017 May;106(5):1439-1451. doi: 10.1016/j.xphs.2017.01.007. Epub 2017 Jan 13. J Pharm Sci. 2017. PMID: 28089685

7

Effects of hepatic impairment on the pharmacokinetics of nilotinib: an open-label, single-dose, parallel-group study.

Yin OQ, Gallagher N, Tanaka C, Fisher D, Sethuraman V, Zhou W, Lin TH, Heuman D, Schran H. Yin OQ, et al. Among authors: lin th. Clin Ther. 2009;31 Pt 2:2459-69. doi: 10.1016/j.clinthera.2009.11.015. Clin Ther. 2009. PMID: 20110053 Clinical Trial.

8

Effect of Renal Impairment on the Pharmacokinetics of Pradigastat, a Novel Diacylglycerol Acyltransferase1 (DGAT1) Inhibitor.

Mita S, Meyers D, Pal P, Lin T, Majumdar T, Rebello S, Sunkara G, Chen J. Mita S, et al. Clin Pharmacokinet. 2015 Jul;54(7):751-60. doi: 10.1007/s40262-015-0234-x. Clin Pharmacokinet. 2015. PMID: 25627776 Clinical Trial.

9

Effect of Hepatic Impairment on the Pharmacokinetics of Pradigastat, a Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitor.

Hirano M, Meyers D, Golla G, Pal P, Pinot P, Lin T, Majumdar T, Rebello S, Sunkara G, Chen J. Hirano M, et al. Clin Pharmacokinet. 2015 Jul;54(7):761-70. doi: 10.1007/s40262-015-0235-9. Clin Pharmacokinet. 2015. PMID: 25633714 Clinical Trial.

10

Growth inhibition and toxicity assessments of cis-3,4-diaryl-α-methylene-γ-butyrolactams in cultured human renal cancer cells and zebrafish embryos.

Lee AS, Lin TH, Liu YY, Wang YH, Cheng SC, Li TS, Sun CY, Chen YH. Lee AS, et al. Among authors: lin th. Biochim Biophys Acta Gen Subj. 2025 Jan 7;1869(3):130761. doi: 10.1016/j.bbagen.2025.130761. Online ahead of print. Biochim Biophys Acta Gen Subj. 2025. PMID: 39788219

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