de Kock C - Search Results

1

2,4-Diaminothienopyrimidines as orally active antimalarial agents.

González Cabrera D, Le Manach C, Douelle F, Younis Y, Feng TS, Paquet T, Nchinda AT, Street LJ, Taylor D, de Kock C, Wiesner L, Duffy S, White KL, Zabiulla KM, Sambandan Y, Bashyam S, Waterson D, Witty MJ, Charman SA, Avery VM, Wittlin S, Chibale K. González Cabrera D, et al. Among authors: de kock c. J Med Chem. 2014 Feb 13;57(3):1014-22. doi: 10.1021/jm401760c. Epub 2014 Jan 28. J Med Chem. 2014. PMID: 24446664

2

Ferrocene-pyrimidine conjugates: Synthesis, electrochemistry, physicochemical properties and antiplasmodial activities.

Chopra R, de Kock C, Smith P, Chibale K, Singh K. Chopra R, et al. Among authors: de kock c. Eur J Med Chem. 2015 Jul 15;100:1-9. doi: 10.1016/j.ejmech.2015.05.043. Epub 2015 May 30. Eur J Med Chem. 2015. PMID: 26057222

3

Synthesis, antiplasmodial activity and mechanistic studies of pyrimidine-5-carbonitrile and quinoline hybrids.

Kaur H, Balzarini J, de Kock C, Smith PJ, Chibale K, Singh K. Kaur H, et al. Among authors: de kock c. Eur J Med Chem. 2015 Aug 28;101:52-62. doi: 10.1016/j.ejmech.2015.06.024. Epub 2015 Jun 12. Eur J Med Chem. 2015. PMID: 26114811

4

Primaquine-pyrimidine hybrids: synthesis and dual-stage antiplasmodial activity.

Kaur H, Machado M, de Kock C, Smith P, Chibale K, Prudêncio M, Singh K. Kaur H, et al. Among authors: de kock c. Eur J Med Chem. 2015 Aug 28;101:266-73. doi: 10.1016/j.ejmech.2015.06.045. Epub 2015 Jun 29. Eur J Med Chem. 2015. PMID: 26142491

5

Pyrrolo[3,4-c]pyridine-1,3(2H)-diones: A Novel Antimycobacterial Class Targeting Mycobacterial Respiration.

van der Westhuyzen R, Winks S, Wilson CR, Boyle GA, Gessner RK, Soares de Melo C, Taylor D, de Kock C, Njoroge M, Brunschwig C, Lawrence N, Rao SP, Sirgel F, van Helden P, Seldon R, Moosa A, Warner DF, Arista L, Manjunatha UH, Smith PW, Street LJ, Chibale K. van der Westhuyzen R, et al. Among authors: de kock c. J Med Chem. 2015 Dec 10;58(23):9371-81. doi: 10.1021/acs.jmedchem.5b01542. Epub 2015 Nov 20. J Med Chem. 2015. PMID: 26551248

6

Synthesis and biological characterisation of ester and amide derivatives of fusidic acid as antiplasmodial agents.

Espinoza-Moraga M, Singh K, Njoroge M, Kaur G, Okombo J, De Kock C, Smith PJ, Wittlin S, Chibale K. Espinoza-Moraga M, et al. Among authors: de kock c. Bioorg Med Chem Lett. 2017 Feb 1;27(3):658-661. doi: 10.1016/j.bmcl.2016.11.077. Epub 2016 Nov 25. Bioorg Med Chem Lett. 2017. PMID: 28012840 Free article.

7

Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy.

Aminake MN, Mahajan A, Kumar V, Hans R, Wiesner L, Taylor D, de Kock C, Grobler A, Smith PJ, Kirschner M, Rethwilm A, Pradel G, Chibale K. Aminake MN, et al. Among authors: de kock c. Bioorg Med Chem. 2012 Sep 1;20(17):5277-89. doi: 10.1016/j.bmc.2012.06.038. Epub 2012 Jun 29. Bioorg Med Chem. 2012. PMID: 22858300

8

Synthesis, characterization, antiparasitic and cytotoxic evaluation of thioureas conjugated to polyamine scaffolds.

Stringer T, Taylor D, de Kock C, Guzgay H, Au A, An SH, Sanchez B, O'Connor R, Patel N, Land KM, Smith PJ, Hendricks DT, Egan TJ, Smith GS. Stringer T, et al. Among authors: de kock c. Eur J Med Chem. 2013 Nov;69:90-8. doi: 10.1016/j.ejmech.2013.08.004. Epub 2013 Aug 11. Eur J Med Chem. 2013. PMID: 24012713

9

Quinoline-pyrimidine hybrids: synthesis, antiplasmodial activity, SAR, and mode of action studies.

Singh K, Kaur H, Smith P, de Kock C, Chibale K, Balzarini J. Singh K, et al. Among authors: de kock c. J Med Chem. 2014 Jan 23;57(2):435-48. doi: 10.1021/jm4014778. Epub 2013 Dec 31. J Med Chem. 2014. PMID: 24354322

10

Synthesis and biological evaluation of 2-aminothiazole derivatives as antimycobacterial and antiplasmodial agents.

Mjambili F, Njoroge M, Naran K, De Kock C, Smith PJ, Mizrahi V, Warner D, Chibale K. Mjambili F, et al. Among authors: de kock c. Bioorg Med Chem Lett. 2014 Jan 15;24(2):560-4. doi: 10.1016/j.bmcl.2013.12.022. Epub 2013 Dec 12. Bioorg Med Chem Lett. 2014. PMID: 24373723

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