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Variation in P450 oxidoreductase (POR) A503V and flavin-containing monooxygenase (FMO)-3 E158K is associated with minor alterations in nicotine metabolism, but does not alter cigarette consumption.
Chenoweth MJ, Zhu AZ, Sanderson Cox L, Ahluwalia JS, Benowitz NL, Tyndale RF. Chenoweth MJ, et al. Among authors: sanderson cox l. Pharmacogenet Genomics. 2014 Mar;24(3):172-6. doi: 10.1097/FPC.0000000000000031. Pharmacogenet Genomics. 2014. PMID: 24448396 Free PMC article.
Transferability of Ancestry-Specific and Cross-Ancestry CYP2A6 Activity Genetic Risk Scores in African and European Populations.
El-Boraie A, Chenoweth MJ, Pouget JG, Benowitz NL, Fukunaga K, Mushiroda T, Kubo M, Nollen NL, Sanderson Cox L, Lerman C, Knight J, Tyndale RF. El-Boraie A, et al. Among authors: sanderson cox l. Clin Pharmacol Ther. 2021 Oct;110(4):975-985. doi: 10.1002/cpt.2135. Epub 2021 Jan 1. Clin Pharmacol Ther. 2021. PMID: 33300144 Free PMC article.
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