Wu CJ - Search Results

1

Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms.

Chang CY, Lyu SY, Liu YC, Hsu NS, Wu CC, Tang CF, Lin KH, Ho JY, Wu CJ, Tsai MD, Li TL. Chang CY, et al. Among authors: wu cc, wu cj. Angew Chem Int Ed Engl. 2014 Feb 10;53(7):1943-8. doi: 10.1002/anie.201307989. Epub 2014 Jan 21. Angew Chem Int Ed Engl. 2014. PMID: 24505011

2

The Mesomeric Effect of Thiazolium on non-Kekulé Diradicals in Pichia stipitis Transketolase.

Hsu NS, Wang YL, Lin KH, Chang CF, Lyu SY, Hsu LJ, Liu YC, Chang CY, Wu CJ, Li TL. Hsu NS, et al. Among authors: wu cj. Angew Chem Int Ed Engl. 2018 Feb 12;57(7):1802-1807. doi: 10.1002/anie.201709799. Epub 2018 Jan 15. Angew Chem Int Ed Engl. 2018. PMID: 29243887

3

Insights into the binding specificity and catalytic mechanism of N-acetylhexosamine 1-phosphate kinases through multiple reaction complexes.

Wang KC, Lyu SY, Liu YC, Chang CY, Wu CJ, Li TL. Wang KC, et al. Among authors: wu cj. Acta Crystallogr D Biol Crystallogr. 2014 May;70(Pt 5):1401-10. doi: 10.1107/S1399004714004209. Epub 2014 Apr 30. Acta Crystallogr D Biol Crystallogr. 2014. PMID: 24816108

4

Structure and mechanism of a nonhaem-iron SAM-dependent C-methyltransferase and its engineering to a hydratase and an O-methyltransferase.

Zou XW, Liu YC, Hsu NS, Huang CJ, Lyu SY, Chan HC, Chang CY, Yeh HW, Lin KH, Wu CJ, Tsai MD, Li TL. Zou XW, et al. Among authors: wu cj. Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1549-60. doi: 10.1107/S1399004714005239. Epub 2014 May 23. Acta Crystallogr D Biol Crystallogr. 2014. PMID: 24914966

5

Multiple complexes of long aliphatic N-acyltransferases lead to synthesis of 2,6-diacylated/2-acyl-substituted glycopeptide antibiotics, effectively killing vancomycin-resistant enterococcus.

Lyu SY, Liu YC, Chang CY, Huang CJ, Chiu YH, Huang CM, Hsu NS, Lin KH, Wu CJ, Tsai MD, Li TL. Lyu SY, et al. Among authors: wu cj. J Am Chem Soc. 2014 Aug 6;136(31):10989-95. doi: 10.1021/ja504125v. Epub 2014 Jul 25. J Am Chem Soc. 2014. PMID: 25095906

6

Structural and chemical trapping of flavin-oxide intermediates reveals substrate-directed reaction multiplicity.

Lin KH, Lyu SY, Yeh HW, Li YS, Hsu NS, Huang CM, Wang YL, Shih HW, Wang ZC, Wu CJ, Li TL. Lin KH, et al. Among authors: wu cj. Protein Sci. 2020 Jul;29(7):1655-1666. doi: 10.1002/pro.3879. Epub 2020 May 26. Protein Sci. 2020. PMID: 32362037 Free PMC article.

7

Glycopeptide biosynthesis: Dbv21/Orf2 from dbv/tcp gene clusters are N-Ac-Glm teicoplanin pseudoaglycone deacetylases and Orf15 from cep gene cluster is a Glc-1-P thymidyltransferase.

Ho JY, Huang YT, Wu CJ, Li YS, Tsai MD, Li TL. Ho JY, et al. Among authors: wu cj. J Am Chem Soc. 2006 Oct 25;128(42):13694-5. doi: 10.1021/ja0644834. J Am Chem Soc. 2006. PMID: 17044690

8

In vitro characterization of enzymes involved in the synthesis of nonproteinogenic residue (2S,3S)-beta-methylphenylalanine in glycopeptide antibiotic mannopeptimycin.

Huang YT, Lyu SY, Chuang PH, Hsu NS, Li YS, Chan HC, Huang CJ, Liu YC, Wu CJ, Yang WB, Li TL. Huang YT, et al. Among authors: wu cj. Chembiochem. 2009 Oct 12;10(15):2480-7. doi: 10.1002/cbic.200900351. Chembiochem. 2009. PMID: 19731276

9

Structural and biochemical interrogation on transketolase from Pichia stipitis for new functionality.

Hsu LJ, Hsu NS, Wang YL, Wu CJ, Li TL. Hsu LJ, et al. Among authors: wu cj. Protein Eng Des Sel. 2016 Nov 1;29(11):513-522. doi: 10.1093/protein/gzw036. Protein Eng Des Sel. 2016. PMID: 27578891

10

Teicoplanin Reprogrammed with the N-Acyl-Glucosamine Pharmacophore at the Penultimate Residue of Aglycone Acquires Broad-Spectrum Antimicrobial Activities Effectively Killing Gram-Positive and -Negative Pathogens.

Huang CM, Lyu SY, Lin KH, Chen CL, Chen MH, Shih HW, Hsu NS, Lo IW, Wang YL, Li YS, Wu CJ, Li TL. Huang CM, et al. Among authors: wu cj. ACS Infect Dis. 2019 Mar 8;5(3):430-442. doi: 10.1021/acsinfecdis.8b00317. Epub 2019 Jan 11. ACS Infect Dis. 2019. PMID: 30599088

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