Schlick T - Search Results

1

Optimal and variant metal-ion routes in DNA polymerase β's conformational pathways.

Li Y, Freudenthal BD, Beard WA, Wilson SH, Schlick T. Li Y, et al. Among authors: schlick t. J Am Chem Soc. 2014 Mar 5;136(9):3630-9. doi: 10.1021/ja412701f. Epub 2014 Feb 21. J Am Chem Soc. 2014. PMID: 24511902 Free PMC article.

2

Polymerase beta simulations suggest that Arg258 rotation is a slow step rather than large subdomain motions per se.

Yang L, Beard WA, Wilson SH, Broyde S, Schlick T. Yang L, et al. Among authors: schlick t. J Mol Biol. 2002 Apr 12;317(5):651-71. doi: 10.1006/jmbi.2002.5450. J Mol Biol. 2002. PMID: 11955015

3

Local deformations revealed by dynamics simulations of DNA polymerase Beta with DNA mismatches at the primer terminus.

Yang L, Beard W, Wilson S, Roux B, Broyde S, Schlick T. Yang L, et al. Among authors: schlick t. J Mol Biol. 2002 Aug 16;321(3):459-78. doi: 10.1016/s0022-2836(02)00617-4. J Mol Biol. 2002. PMID: 12162959

4

Orchestration of cooperative events in DNA synthesis and repair mechanism unraveled by transition path sampling of DNA polymerase beta's closing.

Radhakrishnan R, Schlick T. Radhakrishnan R, et al. Among authors: schlick t. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5970-5. doi: 10.1073/pnas.0308585101. Epub 2004 Apr 6. Proc Natl Acad Sci U S A. 2004. PMID: 15069184 Free PMC article.

5

Highly organized but pliant active site of DNA polymerase beta: compensatory mechanisms in mutant enzymes revealed by dynamics simulations and energy analyses.

Yang L, Beard WA, Wilson SH, Broyde S, Schlick T. Yang L, et al. Among authors: schlick t. Biophys J. 2004 Jun;86(6):3392-408. doi: 10.1529/biophysj.103.036012. Biophys J. 2004. PMID: 15189842 Free PMC article.

6

Critical role of magnesium ions in DNA polymerase beta's closing and active site assembly.

Yang L, Arora K, Beard WA, Wilson SH, Schlick T. Yang L, et al. Among authors: schlick t. J Am Chem Soc. 2004 Jul 14;126(27):8441-53. doi: 10.1021/ja049412o. J Am Chem Soc. 2004. PMID: 15238001

7

In silico evidence for DNA polymerase-beta's substrate-induced conformational change.

Arora K, Schlick T. Arora K, et al. Among authors: schlick t. Biophys J. 2004 Nov;87(5):3088-99. doi: 10.1529/biophysj.104.040915. Biophys J. 2004. PMID: 15507687 Free PMC article.

8

Fidelity discrimination in DNA polymerase beta: differing closing profiles for a mismatched (G:A) versus matched (G:C) base pair.

Radhakrishnan R, Schlick T. Radhakrishnan R, et al. Among authors: schlick t. J Am Chem Soc. 2005 Sep 28;127(38):13245-52. doi: 10.1021/ja052623o. J Am Chem Soc. 2005. PMID: 16173754 Free PMC article.

9

Mismatch-induced conformational distortions in polymerase beta support an induced-fit mechanism for fidelity.

Arora K, Beard WA, Wilson SH, Schlick T. Arora K, et al. Among authors: schlick t. Biochemistry. 2005 Oct 11;44(40):13328-41. doi: 10.1021/bi0507682. Biochemistry. 2005. PMID: 16201758

10

Subtle but variable conformational rearrangements in the replication cycle of Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4) may accommodate lesion bypass.

Wang Y, Arora K, Schlick T. Wang Y, et al. Among authors: schlick t. Protein Sci. 2006 Jan;15(1):135-51. doi: 10.1110/ps.051726906. Epub 2005 Dec 1. Protein Sci. 2006. PMID: 16322565 Free PMC article.

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