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DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans.
Tullet JM, Araiz C, Sanders MJ, Au C, Benedetto A, Papatheodorou I, Clark E, Schmeisser K, Jones D, Schuster EF, Thornton JM, Gems D. Tullet JM, et al. Among authors: schuster ef. PLoS Genet. 2014 Feb 6;10(2):e1004109. doi: 10.1371/journal.pgen.1004109. eCollection 2014 Feb. PLoS Genet. 2014. PMID: 24516399 Free PMC article.
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.
Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, Woods A, Robinson IC, Schuster E, Batterham RL, Kozma SC, Thomas G, Carling D, Okkenhaug K, Thornton JM, Partridge L, Gems D, Withers DJ. Selman C, et al. Science. 2009 Oct 2;326(5949):140-4. doi: 10.1126/science.1177221. Science. 2009. PMID: 19797661 Free PMC article.
DamID in C. elegans reveals longevity-associated targets of DAF-16/FoxO.
Schuster E, McElwee JJ, Tullet JM, Doonan R, Matthijssens F, Reece-Hoyes JS, Hope IA, Vanfleteren JR, Thornton JM, Gems D. Schuster E, et al. Mol Syst Biol. 2010 Aug 10;6:399. doi: 10.1038/msb.2010.54. Mol Syst Biol. 2010. PMID: 20706209 Free PMC article.
Evolutionary conservation of regulated longevity assurance mechanisms.
McElwee JJ, Schuster E, Blanc E, Piper MD, Thomas JH, Patel DS, Selman C, Withers DJ, Thornton JM, Partridge L, Gems D. McElwee JJ, et al. Genome Biol. 2007;8(7):R132. doi: 10.1186/gb-2007-8-7-r132. Genome Biol. 2007. PMID: 17612391 Free PMC article.
45 results