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1,2-Dihydro-2-oxopyridine-3-carboxamides: the C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor.
Lucchesi V, Parkkari T, Savinainen JR, Malfitano AM, Allarà M, Bertini S, Castelli F, Del Carlo S, Laezza C, Ligresti A, Saccomanni G, Bifulco M, Di Marzo V, Macchia M, Manera C. Lucchesi V, et al. Among authors: allara m. Eur J Med Chem. 2014 Mar 3;74:524-32. doi: 10.1016/j.ejmech.2013.10.070. Epub 2014 Jan 21. Eur J Med Chem. 2014. PMID: 24518874
New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists.
Manera C, Cascio MG, Benetti V, Allarà M, Tuccinardi T, Martinelli A, Saccomanni G, Vivoli E, Ghelardini C, Di Marzo V, Ferrarini PL. Manera C, et al. Among authors: allara m. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6505-10. doi: 10.1016/j.bmcl.2007.09.089. Epub 2007 Oct 1. Bioorg Med Chem Lett. 2007. PMID: 17942307
Synthesis, cannabinoid receptor affinity, molecular modeling studies and in vivo pharmacological evaluation of new substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. 2. Effect of the 3-carboxamide substituent on the affinity and selectivity profile.
Silvestri R, Ligresti A, La Regina G, Piscitelli F, Gatti V, Brizzi A, Pasquini S, Lavecchia A, Allarà M, Fantini N, Carai MA, Novellino E, Colombo G, Di Marzo V, Corelli F. Silvestri R, et al. Among authors: allara m. Bioorg Med Chem. 2009 Aug 1;17(15):5549-64. doi: 10.1016/j.bmc.2009.06.027. Epub 2009 Jun 21. Bioorg Med Chem. 2009. PMID: 19595596
Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands.
Silvestri R, Ligresti A, La Regina G, Piscitelli F, Gatti V, Lavecchia A, Brizzi A, Pasquini S, Allarà M, Fantini N, Carai MA, Bigogno C, Rozio MG, Sinisi R, Novellino E, Colombo G, Di Marzo V, Dondio G, Corelli F. Silvestri R, et al. Among authors: allara m. Eur J Med Chem. 2010 Dec;45(12):5878-86. doi: 10.1016/j.ejmech.2010.09.053. Epub 2010 Oct 1. Eur J Med Chem. 2010. PMID: 20943290
Bioactive prenylogous cannabinoid from fiber hemp (Cannabis sativa).
Pollastro F, Taglialatela-Scafati O, Allarà M, Muñoz E, Di Marzo V, De Petrocellis L, Appendino G. Pollastro F, et al. Among authors: allara m. J Nat Prod. 2011 Sep 23;74(9):2019-22. doi: 10.1021/np200500p. Epub 2011 Sep 8. J Nat Prod. 2011. PMID: 21902175
56 results