Kehler J - Search Results

1

Correlating the metabolic stability of psychedelic 5-HT₂A agonists with anecdotal reports of human oral bioavailability.

Leth-Petersen S, Bundgaard C, Hansen M, Carnerup MA, Kehler J, Kristensen JL. Leth-Petersen S, et al. Among authors: kehler j. Neurochem Res. 2014 Oct;39(10):2018-23. doi: 10.1007/s11064-014-1253-y. Epub 2014 Feb 12. Neurochem Res. 2014. PMID: 24519542

2

5-HT_2A/5-HT_2C Receptor Pharmacology and Intrinsic Clearance of N-Benzylphenethylamines Modified at the Primary Site of Metabolism.

Leth-Petersen S, Petersen IN, Jensen AA, Bundgaard C, Bæk M, Kehler J, Kristensen JL. Leth-Petersen S, et al. Among authors: kehler j. ACS Chem Neurosci. 2016 Nov 16;7(11):1614-1619. doi: 10.1021/acschemneuro.6b00265. Epub 2016 Sep 1. ACS Chem Neurosci. 2016. PMID: 27564969

3

Detailed Characterization of the In Vitro Pharmacological and Pharmacokinetic Properties of N-(2-Hydroxybenzyl)-2,5-Dimethoxy-4-Cyanophenylethylamine (25CN-NBOH), a Highly Selective and Brain-Penetrant 5-HT_2A Receptor Agonist.

Jensen AA, McCorvy JD, Leth-Petersen S, Bundgaard C, Liebscher G, Kenakin TP, Bräuner-Osborne H, Kehler J, Kristensen JL. Jensen AA, et al. Among authors: kehler j. J Pharmacol Exp Ther. 2017 Jun;361(3):441-453. doi: 10.1124/jpet.117.239905. Epub 2017 Mar 30. J Pharmacol Exp Ther. 2017. PMID: 28360333

4

In Vitro and In Vivo Evidence for Active Brain Uptake of the GHB Analog HOCPCA by the Monocarboxylate Transporter Subtype 1.

Thiesen L, Kehler J, Clausen RP, Frølund B, Bundgaard C, Wellendorph P. Thiesen L, et al. Among authors: kehler j. J Pharmacol Exp Ther. 2015 Aug;354(2):166-74. doi: 10.1124/jpet.115.224543. Epub 2015 May 18. J Pharmacol Exp Ther. 2015. PMID: 25986445

5

Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as γ-aminobutyric acid(a) receptor agonists.

Petersen JG, Bergmann R, Møller HA, Jørgensen CG, Nielsen B, Kehler J, Frydenvang K, Kristensen J, Balle T, Jensen AA, Kristiansen U, Frølund B. Petersen JG, et al. Among authors: kehler j. J Med Chem. 2013 Feb 14;56(3):993-1006. doi: 10.1021/jm301473k. Epub 2013 Jan 23. J Med Chem. 2013. PMID: 23294161

6

From pan-reactive KV7 channel opener to subtype selective opener/inhibitor by addition of a methyl group.

Blom SM, Rottländer M, Kehler J, Bundgaard C, Schmitt N, Jensen HS. Blom SM, et al. Among authors: kehler j. PLoS One. 2014 Jun 23;9(6):e100209. doi: 10.1371/journal.pone.0100209. eCollection 2014. PLoS One. 2014. PMID: 24956197 Free PMC article.

7

Discovery of α-Substituted Imidazole-4-acetic Acid Analogues as a Novel Class of ρ₁ γ-Aminobutyric Acid Type A Receptor Antagonists with Effect on Retinal Vascular Tone.

Krall J, Brygger BM, Sigurðardóttir SB, Ng CK, Bundgaard C, Kehler J, Nielsen B, Bek T, Jensen AA, Frølund B. Krall J, et al. Among authors: kehler j. ChemMedChem. 2016 Oct 19;11(20):2299-2310. doi: 10.1002/cmdc.201600356. Epub 2016 Sep 13. ChemMedChem. 2016. PMID: 27620323

8

New synthesis and tritium labeling of a selective ligand for studying high-affinity γ-hydroxybutyrate (GHB) binding sites.

Vogensen SB, Marek A, Bay T, Wellendorph P, Kehler J, Bundgaard C, Frølund B, Pedersen MH, Clausen RP. Vogensen SB, et al. Among authors: kehler j. J Med Chem. 2013 Oct 24;56(20):8201-5. doi: 10.1021/jm4011719. Epub 2013 Oct 4. J Med Chem. 2013. PMID: 24053696 Free PMC article.

9

Discovery and development of 11C-Lu AE92686 as a radioligand for PET imaging of phosphodiesterase10A in the brain.

Kehler J, Kilburn JP, Estrada S, Christensen SR, Wall A, Thibblin A, Lubberink M, Bundgaard C, Brennum LT, Steiniger-Brach B, Christoffersen CT, Timmermann S, Kreilgaard M, Antoni G, Bang-Andersen B, Nielsen J. Kehler J, et al. J Nucl Med. 2014 Sep;55(9):1513-8. doi: 10.2967/jnumed.114.140178. Epub 2014 Jul 3. J Nucl Med. 2014. PMID: 24994928 Free article.

10

Novel selective PDE type 1 inhibitors cause vasodilatation and lower blood pressure in rats.

Laursen M, Beck L, Kehler J, Christoffersen CT, Bundgaard C, Mogensen S, Mow TJ, Pinilla E, Knudsen JS, Hedegaard ER, Grunnet M, Simonsen U. Laursen M, et al. Among authors: kehler j. Br J Pharmacol. 2017 Aug;174(15):2563-2575. doi: 10.1111/bph.13868. Epub 2017 Jul 5. Br J Pharmacol. 2017. PMID: 28548283 Free PMC article.

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