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Experimental colitis in mice is attenuated by changes in the levels of endocannabinoid metabolites induced by selective inhibition of fatty acid amide hydrolase (FAAH).
Sałaga M, Mokrowiecka A, Zakrzewski PK, Cygankiewicz A, Leishman E, Sobczak M, Zatorski H, Małecka-Panas E, Kordek R, Storr M, Krajewska WM, Bradshaw HB, Fichna J. Sałaga M, et al. Among authors: kordek r. J Crohns Colitis. 2014 Sep;8(9):998-1009. doi: 10.1016/j.crohns.2014.01.025. Epub 2014 Feb 14. J Crohns Colitis. 2014. PMID: 24530133 Free PMC article.
Novel orally available salvinorin A analog PR-38 protects against experimental colitis and reduces abdominal pain in mice by interaction with opioid and cannabinoid receptors.
Sałaga M, Polepally PR, Zakrzewski PK, Cygankiewicz A, Sobczak M, Kordek R, Zjawiony JK, Krajewska WM, Fichna J. Sałaga M, et al. Among authors: kordek r. Biochem Pharmacol. 2014 Dec 15;92(4):618-26. doi: 10.1016/j.bcp.2014.09.018. Epub 2014 Oct 6. Biochem Pharmacol. 2014. PMID: 25265540
Cyclic derivative of morphiceptin Dmt-cyclo-(D-Lys-Phe-D-Pro-Asp)-NH2(P-317), a mixed agonist of MOP and KOP opioid receptors, exerts anti-inflammatory and anti-tumor activity in colitis and colitis-associated colorectal cancer in mice.
Zielińska M, Szymaszkiewicz A, Jacenik D, Schodel L, Sałaga M, Zatorski H, Kordek R, Becker C, Krajewska WM, Fichna J. Zielińska M, et al. Among authors: kordek r. Eur J Pharmacol. 2020 Oct 15;885:173463. doi: 10.1016/j.ejphar.2020.173463. Epub 2020 Aug 22. Eur J Pharmacol. 2020. PMID: 32835668
Novel selective agonist of GPR18, PSB-KK-1415 exerts potent anti-inflammatory and anti-nociceptive activities in animal models of intestinal inflammation and inflammatory pain.
Fabisiak A, Fabisiak N, Mokrowiecka A, Malecka-Panas E, Jacenik D, Kordek R, Zielińska M, Kieć-Kononowicz K, Fichna J. Fabisiak A, et al. Among authors: kordek r. Neurogastroenterol Motil. 2021 Mar;33(3):e14003. doi: 10.1111/nmo.14003. Epub 2020 Oct 14. Neurogastroenterol Motil. 2021. PMID: 33058313
233 results