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Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes.
Vidadala RS, Ojo KK, Johnson SM, Zhang Z, Leonard SE, Mitra A, Choi R, Reid MC, Keyloun KR, Fox AM, Kennedy M, Silver-Brace T, Hume JC, Kappe S, Verlinde CL, Fan E, Merritt EA, Van Voorhis WC, Maly DJ. Vidadala RS, et al. Among authors: leonard se. Eur J Med Chem. 2014 Mar 3;74:562-73. doi: 10.1016/j.ejmech.2013.12.048. Epub 2014 Jan 11. Eur J Med Chem. 2014. PMID: 24531197 Free PMC article.
Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds.
Crowther GJ, Hillesland HK, Keyloun KR, Reid MC, Lafuente-Monasterio MJ, Ghidelli-Disse S, Leonard SE, He P, Jones JC, Krahn MM, Mo JS, Dasari KS, Fox AM, Boesche M, El Bakkouri M, Rivas KL, Leroy D, Hui R, Drewes G, Maly DJ, Van Voorhis WC, Ojo KK. Crowther GJ, et al. Among authors: leonard se. PLoS One. 2016 Mar 2;11(3):e0149996. doi: 10.1371/journal.pone.0149996. eCollection 2016. PLoS One. 2016. PMID: 26934697 Free PMC article.
Active site profiling reveals coupling between domains in SRC-family kinases.
Krishnamurty R, Brigham JL, Leonard SE, Ranjitkar P, Larson ET, Dale EJ, Merritt EA, Maly DJ. Krishnamurty R, et al. Among authors: leonard se. Nat Chem Biol. 2013 Jan;9(1):43-50. doi: 10.1038/nchembio.1118. Epub 2012 Nov 11. Nat Chem Biol. 2013. PMID: 23143416 Free PMC article.
Isolation and characterization of IgG3 glycan-targeting antibodies with exceptional cross-reactivity for diverse viral families.
Vukovich MJ, Shiakolas AR, Lindenberger J, Richardson RA, Bass LE, Barr M, Liu Y, Go EP, Park CS, May AJ, Sammour S, Kambarami C, Huang X, Janowska K, Edwards RJ, Mansouri K, Spence TN, Abu-Shmais AA, Manamela NP, Richardson SI, Leonard SEW, Gripenstraw KR, Setliff I, Saunders KO, Bonami RH, Ross TM, Desaire H, Moore PL, Parks R, Haynes BF, Sheward DJ, Acharya P, Sautto GA, Georgiev IS. Vukovich MJ, et al. Among authors: leonard sew. PLoS Pathog. 2024 Sep 18;20(9):e1012499. doi: 10.1371/journal.ppat.1012499. eCollection 2024 Sep. PLoS Pathog. 2024. PMID: 39292703 Free PMC article.
20 results