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Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70.
Kang Y, Taldone T, Patel HJ, Patel PD, Rodina A, Gozman A, Maharaj R, Clement CC, Patel MR, Brodsky JL, Young JC, Chiosis G. Kang Y, et al. Among authors: clement cc. J Med Chem. 2014 Feb 27;57(4):1188-207. doi: 10.1021/jm401551n. Epub 2014 Feb 18. J Med Chem. 2014. PMID: 24548207 Free PMC article.
Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3-(phenylthio)pyridines as reversible binders to an allosteric site on heat shock protein 70.
Taldone T, Kang Y, Patel HJ, Patel MR, Patel PD, Rodina A, Patel Y, Gozman A, Maharaj R, Clement CC, Lu A, Young JC, Chiosis G. Taldone T, et al. Among authors: clement cc. J Med Chem. 2014 Feb 27;57(4):1208-24. doi: 10.1021/jm401552y. Epub 2014 Feb 18. J Med Chem. 2014. PMID: 24548239 Free PMC article.
Synthesis of a red-shifted fluorescence polarization probe for Hsp90.
Moulick K, Clement CC, Aguirre J, Kim J, Kang Y, Felts S, Chiosis G. Moulick K, et al. Among authors: clement cc. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4515-8. doi: 10.1016/j.bmcl.2006.06.025. Epub 2006 Jun 22. Bioorg Med Chem Lett. 2006. PMID: 16797988
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.
Rodina A, Vilenchik M, Moulick K, Aguirre J, Kim J, Chiang A, Litz J, Clement CC, Kang Y, She Y, Wu N, Felts S, Wipf P, Massague J, Jiang X, Brodsky JL, Krystal GW, Chiosis G. Rodina A, et al. Among authors: clement cc. Nat Chem Biol. 2007 Aug;3(8):498-507. doi: 10.1038/nchembio.2007.10. Epub 2007 Jul 1. Nat Chem Biol. 2007. PMID: 17603540
Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models.
Caldas-Lopes E, Cerchietti L, Ahn JH, Clement CC, Robles AI, Rodina A, Moulick K, Taldone T, Gozman A, Guo Y, Wu N, de Stanchina E, White J, Gross SS, Ma Y, Varticovski L, Melnick A, Chiosis G. Caldas-Lopes E, et al. Among authors: clement cc. Proc Natl Acad Sci U S A. 2009 May 19;106(20):8368-73. doi: 10.1073/pnas.0903392106. Epub 2009 May 5. Proc Natl Acad Sci U S A. 2009. PMID: 19416831 Free PMC article.
The yeast Hsp110, Sse1p, exhibits high-affinity peptide binding.
Goeckeler JL, Petruso AP, Aguirre J, Clement CC, Chiosis G, Brodsky JL. Goeckeler JL, et al. Among authors: clement cc. FEBS Lett. 2008 Jul 9;582(16):2393-6. doi: 10.1016/j.febslet.2008.05.047. Epub 2008 Jun 6. FEBS Lett. 2008. PMID: 18539149 Free PMC article.
Structural and Biological Interaction of hsc-70 Protein with Phosphatidylserine in Endosomal Microautophagy.
Morozova K, Clement CC, Kaushik S, Stiller B, Arias E, Ahmad A, Rauch JN, Chatterjee V, Melis C, Scharf B, Gestwicki JE, Cuervo AM, Zuiderweg ER, Santambrogio L. Morozova K, et al. Among authors: clement cc. J Biol Chem. 2016 Aug 26;291(35):18096-106. doi: 10.1074/jbc.M116.736744. Epub 2016 Jul 12. J Biol Chem. 2016. PMID: 27405763 Free PMC article.
66 results