Hagedorn PH - Search Results

1

A Kinetic Model Explains Why Shorter and Less Affine Enzyme-recruiting Oligonucleotides Can Be More Potent.

Pedersen L, Hagedorn PH, Lindholm MW, Lindow M. Pedersen L, et al. Among authors: hagedorn ph. Mol Ther Nucleic Acids. 2014 Feb 18;3(2):e149. doi: 10.1038/mtna.2013.72. Mol Ther Nucleic Acids. 2014. PMID: 24549300 Free PMC article.

2

Targeting Repeated Regions Unique to a Gene Is an Effective Strategy for Discovering Potent and Efficacious Antisense Oligonucleotides.

Pedersen L, Hagedorn P, Vikeså J, Karlsen ST, Særmark P, Koch T, Lindow M. Pedersen L, et al. Mol Ther Nucleic Acids. 2020 Mar 6;19:124-131. doi: 10.1016/j.omtn.2019.10.040. Epub 2019 Nov 15. Mol Ther Nucleic Acids. 2020. PMID: 31846799 Free PMC article.

3

Managing the sequence-specificity of antisense oligonucleotides in drug discovery.

Hagedorn PH, Hansen BR, Koch T, Lindow M. Hagedorn PH, et al. Nucleic Acids Res. 2017 Mar 17;45(5):2262-2282. doi: 10.1093/nar/gkx056. Nucleic Acids Res. 2017. PMID: 28426096 Free PMC article. Review.

4

Dissecting the target specificity of RNase H recruiting oligonucleotides using massively parallel reporter analysis of short RNA motifs.

Rukov JL, Hagedorn PH, Høy IB, Feng Y, Lindow M, Vinther J. Rukov JL, et al. Among authors: hagedorn ph. Nucleic Acids Res. 2015 Sep 30;43(17):8476-87. doi: 10.1093/nar/gkv759. Epub 2015 Jul 28. Nucleic Acids Res. 2015. PMID: 26220183 Free PMC article.

5

RNase H sequence preferences influence antisense oligonucleotide efficiency.

Kielpinski LJ, Hagedorn PH, Lindow M, Vinther J. Kielpinski LJ, et al. Among authors: hagedorn ph. Nucleic Acids Res. 2017 Dec 15;45(22):12932-12944. doi: 10.1093/nar/gkx1073. Nucleic Acids Res. 2017. PMID: 29126318 Free PMC article.

6

Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice.

Hagedorn PH, Pontoppidan M, Bisgaard TS, Berrera M, Dieckmann A, Ebeling M, Møller MR, Hudlebusch H, Jensen ML, Hansen HF, Koch T, Lindow M. Hagedorn PH, et al. Nucleic Acids Res. 2018 Jun 20;46(11):5366-5380. doi: 10.1093/nar/gky397. Nucleic Acids Res. 2018. PMID: 29790953 Free PMC article.

7

RNase H sequence preferences influence antisense oligonucleotide efficiency.

Kiełpiński ŁJ, Hagedorn PH, Lindow M, Vinther J. Kiełpiński ŁJ, et al. Among authors: hagedorn ph. Nucleic Acids Res. 2019 Mar 18;47(5):2701. doi: 10.1093/nar/gkz065. Nucleic Acids Res. 2019. PMID: 30715421 Free PMC article. No abstract available.

8

Identifying Suitable Target Regions and Analyzing Off-Target Effects of Therapeutic Oligonucleotides.

Pedersen L, Hagedorn PH, Koch T. Pedersen L, et al. Among authors: hagedorn ph. Methods Mol Biol. 2019;2036:261-282. doi: 10.1007/978-1-4939-9670-4_16. Methods Mol Biol. 2019. PMID: 31410803

9

Hepatotoxic potential of therapeutic oligonucleotides can be predicted from their sequence and modification pattern.

Hagedorn PH, Yakimov V, Ottosen S, Kammler S, Nielsen NF, Høg AM, Hedtjärn M, Meldgaard M, Møller MR, Orum H, Koch T, Lindow M. Hagedorn PH, et al. Nucleic Acid Ther. 2013 Oct;23(5):302-10. doi: 10.1089/nat.2013.0436. Epub 2013 Aug 16. Nucleic Acid Ther. 2013. PMID: 23952551 Free PMC article.

10

Independent component and pathway-based analysis of miRNA-regulated gene expression in a model of type 1 diabetes.

Bang-Berthelsen CH, Pedersen L, Fløyel T, Hagedorn PH, Gylvin T, Pociot F. Bang-Berthelsen CH, et al. Among authors: hagedorn ph. BMC Genomics. 2011 Feb 4;12:97. doi: 10.1186/1471-2164-12-97. BMC Genomics. 2011. PMID: 21294859 Free PMC article.

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