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Page 1
Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1.
Le Manach C, Gonzàlez Cabrera D, Douelle F, Nchinda AT, Younis Y, Taylor D, Wiesner L, White KL, Ryan E, March C, Duffy S, Avery VM, Waterson D, Witty MJ, Wittlin S, Charman SA, Street LJ, Chibale K. Le Manach C, et al. Among authors: charman sa. J Med Chem. 2014 Mar 27;57(6):2789-98. doi: 10.1021/jm500098s. Epub 2014 Mar 13. J Med Chem. 2014. PMID: 24568587
Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.
Dong Y, Chollet J, Matile H, Charman SA, Chiu FC, Charman WN, Scorneaux B, Urwyler H, Santo Tomas J, Scheurer C, Snyder C, Dorn A, Wang X, Karle JM, Tang Y, Wittlin S, Brun R, Vennerstrom JL. Dong Y, et al. Among authors: charman wn, charman sa. J Med Chem. 2005 Jul 28;48(15):4953-61. doi: 10.1021/jm049040u. J Med Chem. 2005. PMID: 16033274
Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes.
Dong Y, Tang Y, Chollet J, Matile H, Wittlin S, Charman SA, Charman WN, Tomas JS, Scheurer C, Snyder C, Scorneaux B, Bajpai S, Alexander SA, Wang X, Padmanilayam M, Cheruku SR, Brun R, Vennerstrom JL. Dong Y, et al. Among authors: charman wn, charman sa. Bioorg Med Chem. 2006 Sep 15;14(18):6368-82. doi: 10.1016/j.bmc.2006.05.041. Epub 2006 Jun 8. Bioorg Med Chem. 2006. PMID: 16759871
Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine.
Padmanilayam M, Scorneaux B, Dong Y, Chollet J, Matile H, Charman SA, Creek DJ, Charman WN, Tomas JS, Scheurer C, Wittlin S, Brun R, Vennerstrom JL. Padmanilayam M, et al. Among authors: charman wn, charman sa. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5542-5. doi: 10.1016/j.bmcl.2006.08.046. Epub 2006 Aug 22. Bioorg Med Chem Lett. 2006. PMID: 16931006
Weak base dispiro-1,2,4-trioxolanes: potent antimalarial ozonides.
Tang Y, Dong Y, Wittlin S, Charman SA, Chollet J, Chiu FC, Charman WN, Matile H, Urwyler H, Dorn A, Bajpai S, Wang X, Padmanilayam M, Karle JM, Brun R, Vennerstrom JL. Tang Y, et al. Among authors: charman wn, charman sa. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1260-5. doi: 10.1016/j.bmcl.2006.12.007. Epub 2006 Dec 15. Bioorg Med Chem Lett. 2007. PMID: 17189686
Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277.
Zhou L, Alker A, Ruf A, Wang X, Chiu FC, Morizzi J, Charman SA, Charman WN, Scheurer C, Wittlin S, Dong Y, Hunziker D, Vennerstrom JL. Zhou L, et al. Among authors: charman wn, charman sa. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1555-8. doi: 10.1016/j.bmcl.2008.01.087. Epub 2008 Jan 30. Bioorg Med Chem Lett. 2008. PMID: 18262417
198 results