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Antiproliferative and uncoupling effects of delocalized, lipophilic, cationic gallic acid derivatives on cancer cell lines. Validation in vivo in singenic mice.
Jara JA, Castro-Castillo V, Saavedra-Olavarría J, Peredo L, Pavanni M, Jaña F, Letelier ME, Parra E, Becker MI, Morello A, Kemmerling U, Maya JD, Ferreira J. Jara JA, et al. Among authors: parra e. J Med Chem. 2014 Mar 27;57(6):2440-54. doi: 10.1021/jm500174v. Epub 2014 Mar 17. J Med Chem. 2014. PMID: 24568614
Destabilization of mitochondrial functions as a target against breast cancer progression: Role of TPP(+)-linked-polyhydroxybenzoates.
Sandoval-Acuña C, Fuentes-Retamal S, Guzmán-Rivera D, Peredo-Silva L, Madrid-Rojas M, Rebolledo S, Castro-Castillo V, Pavani M, Catalán M, Maya JD, Jara JA, Parra E, Calaf GM, Speisky H, Ferreira J. Sandoval-Acuña C, et al. Among authors: parra e. Toxicol Appl Pharmacol. 2016 Oct 15;309:2-14. doi: 10.1016/j.taap.2016.08.018. Epub 2016 Aug 20. Toxicol Appl Pharmacol. 2016. PMID: 27554043
Derivatives of alkyl gallate triphenylphosphonium exhibit antitumor activity in a syngeneic murine model of mammary adenocarcinoma.
Peredo-Silva L, Fuentes-Retamal S, Sandoval-Acuña C, Pavani M, Maya JD, Castro-Castillo V, Madrid-Rojas M, Rebolledo S, Kemmerling U, Parra E, Ferreira J. Peredo-Silva L, et al. Among authors: parra e. Toxicol Appl Pharmacol. 2017 Aug 15;329:334-346. doi: 10.1016/j.taap.2017.06.017. Epub 2017 Jun 21. Toxicol Appl Pharmacol. 2017. PMID: 28647477
An ortho-carbonyl substituted hydroquinone derivative is an anticancer agent that acts by inhibiting mitochondrial bioenergetics and by inducing G₂/M-phase arrest in mammary adenocarcinoma TA3.
Urra FA, Martínez-Cifuentes M, Pavani M, Lapier M, Jaña-Prado F, Parra E, Maya JD, Pessoa-Mahana H, Ferreira J, Araya-Maturana R. Urra FA, et al. Among authors: parra e. Toxicol Appl Pharmacol. 2013 Mar 15;267(3):218-27. doi: 10.1016/j.taap.2012.12.023. Epub 2013 Jan 17. Toxicol Appl Pharmacol. 2013. PMID: 23333614
593 results