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Page 1
Cathepsin C inhibitors: property optimization and identification of a clinical candidate.
Furber M, Tiden AK, Gardiner P, Mete A, Ford R, Millichip I, Stein L, Mather A, Kinchin E, Luckhurst C, Barber S, Cage P, Sanganee H, Austin R, Chohan K, Beri R, Thong B, Wallace A, Oreffo V, Hutchinson R, Harper S, Debreczeni J, Breed J, Wissler L, Edman K. Furber M, et al. Among authors: stein l. J Med Chem. 2014 Mar 27;57(6):2357-67. doi: 10.1021/jm401705g. Epub 2014 Mar 14. J Med Chem. 2014. PMID: 24592859
Design and synthesis of a novel and potent series of inhibitors of cytosolic phospholipase A(2) based on a 1,3-disubstituted propan-2-one skeleton.
Connolly S, Bennion C, Botterell S, Croshaw PJ, Hallam C, Hardy K, Hartopp P, Jackson CG, King SJ, Lawrence L, Mete A, Murray D, Robinson DH, Smith GM, Stein L, Walters I, Wells E, Withnall WJ. Connolly S, et al. Among authors: stein l. J Med Chem. 2002 Mar 14;45(6):1348-62. doi: 10.1021/jm011050x. J Med Chem. 2002. PMID: 11882004
Scaffold-hopping with zwitterionic CCR3 antagonists: identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092.
Bahl A, Barton P, Bowers K, Caffrey MV, Denton R, Gilmour P, Hawley S, Linannen T, Luckhurst CA, Mochel T, Perry MW, Riley RJ, Roe E, Springthorpe B, Stein L, Webborn P. Bahl A, et al. Among authors: stein l. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6694-9. doi: 10.1016/j.bmcl.2012.08.103. Epub 2012 Sep 11. Bioorg Med Chem Lett. 2012. PMID: 23021991
Synthesis and evaluation of substrate-mimicking cytosolic phospholipase A2 inhibitors--reducing the lipophilicity of the arachidonyl chain isostere.
Walters I, Bennion C, Connolly S, Croshaw PJ, Hardy K, Hartopp P, Jackson CG, King SJ, Lawrence L, Mete A, Murray D, Robinson DH, Stein L, Wells E, John Withnall W. Walters I, et al. Among authors: stein l. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3645-9. doi: 10.1016/j.bmcl.2004.05.024. Bioorg Med Chem Lett. 2004. PMID: 15203135
Comparison of the effectiveness of awake-prone positioning and high-flow nasal oxygen in patients with COVID-19-related acute respiratory failure between different waves.
Esperatti M, Olmos M, Busico M, Gallardo A, Vitali A, Quintana J, Kakisu H, Ferreyro BL, Fuentes NA; Argentine Collaborative Group on High Flow and Prone Positioning; Osatnik J, Saavedra SN, Matarrese A, Rebaza Niquin GD, Wasinger EG, Mast G, Andrada FJ, Lagazio AI, Romano NE, Laiz MM, Garcia Urrutia J, Mogaadouro MA, Seifert MR, Mastroberti E, Navarro Moreno C, Miranda Tirado A, Constanza Viñas M, Pintos JM, Gonzalez ME, Mateos M, Barbaresi V, Grimbeek AE, Stein L, Latronico AJ, Menéndez SL, Basualdo AD, Castrillo R. Esperatti M, et al. Among authors: stein l. Crit Care Sci. 2024 Dec 20;36:e20240065en. doi: 10.62675/2965-2774.20240065-en. eCollection 2024. Crit Care Sci. 2024. PMID: 39775433 Free article. English, Portuguese.
1,542 results