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23,767 results

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Application of encoded library technology (ELT) to a protein-protein interaction target: discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists.
Kollmann CS, Bai X, Tsai CH, Yang H, Lind KE, Skinner SR, Zhu Z, Israel DI, Cuozzo JW, Morgan BA, Yuki K, Xie C, Springer TA, Shimaoka M, Evindar G. Kollmann CS, et al. Among authors: zhu z. Bioorg Med Chem. 2014 Apr 1;22(7):2353-65. doi: 10.1016/j.bmc.2014.01.050. Epub 2014 Feb 7. Bioorg Med Chem. 2014. PMID: 24593905
Encoded library technology screening of hepatitis C virus NS4B yields a small-molecule compound series with in vitro replicon activity.
Arico-Muendel C, Zhu Z, Dickson H, Parks D, Keicher J, Deng J, Aquilani L, Coppo F, Graybill T, Lind K, Peat A, Thomson M. Arico-Muendel C, et al. Among authors: zhu z. Antimicrob Agents Chemother. 2015;59(6):3450-9. doi: 10.1128/AAC.00070-15. Epub 2015 Mar 30. Antimicrob Agents Chemother. 2015. PMID: 25824229 Free PMC article.
Design and Application of a DNA-Encoded Macrocyclic Peptide Library.
Zhu Z, Shaginian A, Grady LC, O'Keeffe T, Shi XE, Davie CP, Simpson GL, Messer JA, Evindar G, Bream RN, Thansandote PP, Prentice NR, Mason AM, Pal S. Zhu Z, et al. ACS Chem Biol. 2018 Jan 19;13(1):53-59. doi: 10.1021/acschembio.7b00852. Epub 2017 Dec 4. ACS Chem Biol. 2018. PMID: 29185700
DNA-Encoded Macrocyclic Peptide Library.
Zhu Z, Shaginian A, Grady SC, Davie CP, Lind K, Pal S, Thansandote P, Simpson GL. Zhu Z, et al. Methods Mol Biol. 2019;2001:273-284. doi: 10.1007/978-1-4939-9504-2_12. Methods Mol Biol. 2019. PMID: 31134575
DNA-Encoded Library Technology-Based Discovery, Lead Optimization, and Prodrug Strategy toward Structurally Unique Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors.
Kazmierski WM, Xia B, Miller J, De la Rosa M, Favre D, Dunham RM, Washio Y, Zhu Z, Wang F, Mebrahtu M, Deng H, Basilla J, Wang L, Evindar G, Fan L, Olszewski A, Prabhu N, Davie C, Messer JA, Samano V. Kazmierski WM, et al. Among authors: zhu z. J Med Chem. 2020 Apr 9;63(7):3552-3562. doi: 10.1021/acs.jmedchem.9b01799. Epub 2020 Mar 19. J Med Chem. 2020. PMID: 32073266
Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening.
Tian X, Suarez D, Thomson D, Li W, King EA, LaFrance L, Boehm J, Barton L, Di Marco C, Martyr C, Thalji R, Medina J, Knight S, Heerding D, Gao E, Nartey E, Cecconie T, Nixon C, Zhang G, Berrodin TJ, Phelps C, Patel A, Bai X, Lind K, Prabhu N, Messer J, Zhu Z, Shewchuk L, Reid R, Graves AP, McHugh C, Mangatt B. Tian X, et al. Among authors: zhu z. J Med Chem. 2022 Nov 10;65(21):14391-14408. doi: 10.1021/acs.jmedchem.2c00670. Epub 2022 Oct 27. J Med Chem. 2022. PMID: 36302181
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