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Loss of polycystin-1 inhibits Bicc1 expression during mouse development.
Lian P, Li A, Li Y, Liu H, Liang D, Hu B, Lin D, Jiang T, Moeckel G, Qin D, Wu G. Lian P, et al. Among authors: wu g. PLoS One. 2014 Mar 3;9(3):e88816. doi: 10.1371/journal.pone.0088816. eCollection 2014. PLoS One. 2014. PMID: 24594709 Free PMC article.
Polycystin-2 expression is regulated by a PC2-binding domain in the intracellular portion of fibrocystin.
Kim I, Li C, Liang D, Chen XZ, Coffy RJ, Ma J, Zhao P, Wu G. Kim I, et al. Among authors: wu g. J Biol Chem. 2008 Nov 14;283(46):31559-66. doi: 10.1074/jbc.M805452200. Epub 2008 Sep 9. J Biol Chem. 2008. PMID: 18782757 Free PMC article.
Our recent study reported that a deficiency in FPC increases the severity of cystic disease in Pkd2 mutants and down-regulates PC2 in vivo, but the precise molecular mechanism of these effects is unknown (Kim, I., Fu, Y., Hui, K., Moeckel, G., Mai, W., Li, C., Liang, D., Z …
Our recent study reported that a deficiency in FPC increases the severity of cystic disease in Pkd2 mutants and down-regulates PC2 in vivo, …
Conditional mutation of Pkd2 causes cystogenesis and upregulates beta-catenin.
Kim I, Ding T, Fu Y, Li C, Cui L, Li A, Lian P, Liang D, Wang DW, Guo C, Ma J, Zhao P, Coffey RJ, Zhan Q, Wu G. Kim I, et al. Among authors: wu g. J Am Soc Nephrol. 2009 Dec;20(12):2556-69. doi: 10.1681/ASN.2009030271. Epub 2009 Nov 25. J Am Soc Nephrol. 2009. PMID: 19939939 Free PMC article.
PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells.
Zhang MZ, Mai W, Li C, Cho SY, Hao C, Moeckel G, Zhao R, Kim I, Wang J, Xiong H, Wang H, Sato Y, Wu Y, Nakanuma Y, Lilova M, Pei Y, Harris RC, Li S, Coffey RJ, Sun L, Wu D, Chen XZ, Breyer MD, Zhao ZJ, McKanna JA, Wu G. Zhang MZ, et al. Among authors: wu y, wu g, wu d. Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2311-6. doi: 10.1073/pnas.0400073101. Proc Natl Acad Sci U S A. 2004. PMID: 14983006 Free PMC article.
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