Tsantrizos YS - Search Results

1

Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate.

Park J, Lin YS, Tsantrizos YS, Berghuis AM. Park J, et al. Among authors: tsantrizos ys. Acta Crystallogr F Struct Biol Commun. 2014 Mar;70(Pt 3):299-304. doi: 10.1107/S2053230X14002106. Epub 2014 Feb 19. Acta Crystallogr F Struct Biol Commun. 2014. PMID: 24598914 Free PMC article.

2

Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase.

De Schutter JW, Zaretsky S, Welbourn S, Pause A, Tsantrizos YS. De Schutter JW, et al. Among authors: tsantrizos ys. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5781-6. doi: 10.1016/j.bmcl.2010.07.133. Epub 2010 Aug 11. Bioorg Med Chem Lett. 2010. PMID: 20801032

3

Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells.

Lin YS, Park J, De Schutter JW, Huang XF, Berghuis AM, Sebag M, Tsantrizos YS. Lin YS, et al. Among authors: tsantrizos ys. J Med Chem. 2012 Apr 12;55(7):3201-15. doi: 10.1021/jm201657x. Epub 2012 Mar 19. J Med Chem. 2012. PMID: 22390415

4

Design of potent bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase via targeted interactions with the active site 'capping' phenyls.

De Schutter JW, Shaw J, Lin YS, Tsantrizos YS. De Schutter JW, et al. Among authors: tsantrizos ys. Bioorg Med Chem. 2012 Sep 15;20(18):5583-91. doi: 10.1016/j.bmc.2012.07.019. Epub 2012 Jul 24. Bioorg Med Chem. 2012. PMID: 22884353

5

Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure.

Park J, Lin YS, De Schutter JW, Tsantrizos YS, Berghuis AM. Park J, et al. Among authors: tsantrizos ys. BMC Struct Biol. 2012 Dec 12;12:32. doi: 10.1186/1472-6807-12-32. BMC Struct Biol. 2012. PMID: 23234314 Free PMC article.

6

Discovery of thienopyrimidine-based inhibitors of the human farnesyl pyrophosphate synthase--parallel synthesis of analogs via a trimethylsilyl ylidene intermediate.

Leung CY, Langille AM, Mancuso J, Tsantrizos YS. Leung CY, et al. Among authors: tsantrizos ys. Bioorg Med Chem. 2013 Apr 15;21(8):2229-2240. doi: 10.1016/j.bmc.2013.02.006. Epub 2013 Feb 18. Bioorg Med Chem. 2013. PMID: 23477945

7

Thienopyrimidine bisphosphonate (ThPBP) inhibitors of the human farnesyl pyrophosphate synthase: optimization and characterization of the mode of inhibition.

Leung CY, Park J, De Schutter JW, Sebag M, Berghuis AM, Tsantrizos YS. Leung CY, et al. Among authors: tsantrizos ys. J Med Chem. 2013 Oct 24;56(20):7939-50. doi: 10.1021/jm400946f. Epub 2013 Oct 3. J Med Chem. 2013. PMID: 23998921

8

Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases.

De Schutter JW, Park J, Leung CY, Gormley P, Lin YS, Hu Z, Berghuis AM, Poirier J, Tsantrizos YS. De Schutter JW, et al. Among authors: tsantrizos ys. J Med Chem. 2014 Jul 10;57(13):5764-76. doi: 10.1021/jm500629e. Epub 2014 Jun 23. J Med Chem. 2014. PMID: 24911527

9

Human isoprenoid synthase enzymes as therapeutic targets.

Park J, Matralis AN, Berghuis AM, Tsantrizos YS. Park J, et al. Among authors: tsantrizos ys. Front Chem. 2014 Jul 22;2:50. doi: 10.3389/fchem.2014.00050. eCollection 2014. Front Chem. 2014. PMID: 25101260 Free PMC article. Review.

10

Modular assembly of purine-like bisphosphonates as inhibitors of HIV-1 reverse transcriptase.

Lacbay CM, Mancuso J, Lin YS, Bennett N, Götte M, Tsantrizos YS. Lacbay CM, et al. Among authors: tsantrizos ys. J Med Chem. 2014 Sep 11;57(17):7435-49. doi: 10.1021/jm501010f. Epub 2014 Aug 29. J Med Chem. 2014. PMID: 25144111

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