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Page 1
Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases.
von Nussbaum F, Li VM, Allerheiligen S, Anlauf S, Bärfacker L, Bechem M, Delbeck M, Fitzgerald MF, Gerisch M, Gielen-Haertwig H, Haning H, Karthaus D, Lang D, Lustig K, Meibom D, Mittendorf J, Rosentreter U, Schäfer M, Schäfer S, Schamberger J, Telan LA, Tersteegen A. von Nussbaum F, et al. Among authors: delbeck m. ChemMedChem. 2015 Jul;10(7):1163-73. doi: 10.1002/cmdc.201500131. Epub 2015 Jun 17. ChemMedChem. 2015. PMID: 26083237 Free PMC article.
Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: in vivo Efficacy of the Polar Pyrimidopyridazine BAY-8040 in a Pulmonary Arterial Hypertension Rat Model.
von Nussbaum F, Li VM, Meibom D, Anlauf S, Bechem M, Delbeck M, Gerisch M, Harrenga A, Karthaus D, Lang D, Lustig K, Mittendorf J, Schäfer M, Schäfer S, Schamberger J. von Nussbaum F, et al. Among authors: delbeck m. ChemMedChem. 2016 Jan 19;11(2):199-206. doi: 10.1002/cmdc.201500269. Epub 2015 Sep 3. ChemMedChem. 2016. PMID: 26333652
Vascular Protection and Decongestion Without Renin-Angiotensin-Aldosterone System Stimulation Mediated by a Novel Dual-Acting Vasopressin V1a/V2 Receptor Antagonist.
Kolkhof P, Pook E, Pavkovic M, Kretschmer A, Buchmüller A, Tinel H, Delbeck M, Mondritzki T, Wasnaire P, Dinh W, Truebel H, Hüser J, Schmeck C. Kolkhof P, et al. Among authors: delbeck m. J Cardiovasc Pharmacol. 2019 Jul;74(1):44-52. doi: 10.1097/FJC.0000000000000677. J Cardiovasc Pharmacol. 2019. PMID: 31274842
Inhaled mosliciguat (BAY 1237592): targeting pulmonary vasculature via activating apo-sGC.
Becker-Pelster EM, Hahn MG, Delbeck M, Dietz L, Hüser J, Kopf J, Kraemer T, Marquardt T, Mondritzki T, Nagelschmitz J, Nikkho SM, Pires PV, Tinel H, Weimann G, Wunder F, Sandner P, Schuhmacher J, Stasch JP, Truebel HKF. Becker-Pelster EM, et al. Among authors: delbeck m. Respir Res. 2022 Oct 1;23(1):272. doi: 10.1186/s12931-022-02189-1. Respir Res. 2022. PMID: 36183104 Free PMC article.
Preclinical in vitro and in vivo evaluation of [11C]ORM-13070 as PET ligand for alpha-2C adrenergic receptor occupancy using PET imaging in non-human primates.
Piel I, Constantinescu CC, de la Puente Bethencourt D, Bonsall DR, Rabiner EA, Zasadny KR, Llopis Amenta A, Wells LA, Poethko T, Prange W, Delbeck M. Piel I, et al. Among authors: delbeck m. J Cereb Blood Flow Metab. 2024 Oct 31:271678X241291949. doi: 10.1177/0271678X241291949. Online ahead of print. J Cereb Blood Flow Metab. 2024. PMID: 39479946 Free PMC article.
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