Perlmutter P - Search Results

1

Preparation of crystals for characterizing the Grb7 SH2 domain before and after complex formation with a bicyclic peptide antagonist.

Ambaye ND, Gunzburg MJ, Traore DA, Del Borgo MP, Perlmutter P, Wilce MC, Wilce JA. Ambaye ND, et al. Among authors: perlmutter p. Acta Crystallogr F Struct Biol Commun. 2014 Feb;70(Pt 2):182-6. doi: 10.1107/S2053230X13033414. Epub 2014 Jan 21. Acta Crystallogr F Struct Biol Commun. 2014. PMID: 24637751 Free PMC article.

2

Uptake of a cell permeable G7-18NATE contruct into cells and binding with the Grb-7-SH2 domain.

Ambaye ND, Lim RC, Clayton DJ, Gunzburg MJ, Price JT, Pero SC, Krag DN, Wilce MC, Aguilar MI, Perlmutter P, Wilce JA. Ambaye ND, et al. Among authors: perlmutter p. Biopolymers. 2011;96(2):181-8. doi: 10.1002/bip.21403. Biopolymers. 2011. PMID: 20564009

3

Preparation and crystallization of the Grb7 SH2 domain in complex with the G7-18NATE nonphosphorylated cyclic inhibitor peptide.

Yap MY, Wilce MC, Clayton DJ, Perlmutter P, Aguilar MI, Wilce JA. Yap MY, et al. Among authors: perlmutter p. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Dec 1;66(Pt 12):1640-3. doi: 10.1107/S1744309110041850. Epub 2010 Nov 26. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID: 21139214 Free PMC article.

4

Structural basis of binding by cyclic nonphosphorylated peptide antagonists of Grb7 implicated in breast cancer progression.

Ambaye ND, Pero SC, Gunzburg MJ, Yap M, Clayton DJ, Del Borgo MP, Perlmutter P, Aguilar MI, Shukla GS, Peletskaya E, Cookson MM, Krag DN, Wilce MC, Wilce JA. Ambaye ND, et al. Among authors: perlmutter p. J Mol Biol. 2011 Sep 23;412(3):397-411. doi: 10.1016/j.jmb.2011.07.030. Epub 2011 Jul 23. J Mol Biol. 2011. PMID: 21802427

5

Design and testing of bicyclic inhibitors of Grb7--are two cycles better than one?

Gunzburg MJ, Ambaye ND, Del Borgo MP, Perlmutter P, Wilce JA. Gunzburg MJ, et al. Among authors: perlmutter p. Biopolymers. 2013 Sep;100(5):543-9. doi: 10.1002/bip.22237. Biopolymers. 2013. PMID: 23505041

6

Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target.

Watson GM, Gunzburg MJ, Ambaye ND, Lucas WA, Traore DA, Kulkarni K, Cergol KM, Payne RJ, Panjikar S, Pero SC, Perlmutter P, Wilce MC, Wilce JA. Watson GM, et al. Among authors: perlmutter p. J Med Chem. 2015 Oct 8;58(19):7707-18. doi: 10.1021/acs.jmedchem.5b00609. Epub 2015 Sep 23. J Med Chem. 2015. PMID: 26359549

7

Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.

Gunzburg MJ, Kulkarni K, Watson GM, Ambaye ND, Del Borgo MP, Brandt R, Pero SC, Perlmutter P, Wilce MC, Wilce JA. Gunzburg MJ, et al. Among authors: perlmutter p. Sci Rep. 2016 Jun 3;6:27060. doi: 10.1038/srep27060. Sci Rep. 2016. PMID: 27257138 Free PMC article.

8

Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target.

Watson GM, Kulkarni K, Sang J, Ma X, Gunzburg MJ, Perlmutter P, Wilce MCJ, Wilce JA. Watson GM, et al. Among authors: perlmutter p. J Med Chem. 2017 Nov 22;60(22):9349-9359. doi: 10.1021/acs.jmedchem.7b01320. Epub 2017 Nov 10. J Med Chem. 2017. PMID: 29083893

9

Synthesis of stapled beta3-peptides through ring-closing metathesis.

Bergman YE, Del Borgo MP, Gopalan RD, Jalal S, Unabia SE, Ciampini M, Clayton DJ, Fletcher JM, Mulder RJ, Wilce JA, Aguilar MI, Perlmutter P. Bergman YE, et al. Among authors: perlmutter p. Org Lett. 2009 Oct 1;11(19):4438-40. doi: 10.1021/ol901803d. Org Lett. 2009. PMID: 19719157

10

Conformational stability studies of a stapled hexa-β3-peptide library.

Gopalan RD, Del Borgo MP, Bergman YE, Unabia S, Mulder RJ, Wilce MC, Wilce JA, Aguilar MI, Perlmutter P. Gopalan RD, et al. Among authors: perlmutter p. Org Biomol Chem. 2012 Mar 7;10(9):1802-6. doi: 10.1039/c2ob06617c. Epub 2012 Jan 18. Org Biomol Chem. 2012. PMID: 22252416

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