Lietha D - Search Results

1

Inhibition of both focal adhesion kinase and fibroblast growth factor receptor 2 pathways induces anti-tumor and anti-angiogenic activities.

Dao P, Jarray R, Smith N, Lepelletier Y, Le Coq J, Lietha D, Hadj-Slimane R, Herbeuval JP, Garbay C, Raynaud F, Chen H. Dao P, et al. Among authors: lietha d. Cancer Lett. 2014 Jun 28;348(1-2):88-99. doi: 10.1016/j.canlet.2014.03.007. Epub 2014 Mar 19. Cancer Lett. 2014. PMID: 24657306

2

Design, synthesis, and evaluation of novel imidazo[1,2-a][1,3,5]triazines and their derivatives as focal adhesion kinase inhibitors with antitumor activity.

Dao P, Smith N, Tomkiewicz-Raulet C, Yen-Pon E, Camacho-Artacho M, Lietha D, Herbeuval JP, Coumoul X, Garbay C, Chen H. Dao P, et al. Among authors: lietha d. J Med Chem. 2015 Jan 8;58(1):237-51. doi: 10.1021/jm500784e. Epub 2014 Sep 11. J Med Chem. 2015. PMID: 25180654

3

Synthesis of novel 1,2,4-triazine scaffold as FAK inhibitors with antitumor activity.

Dao P, Lietha D, Etheve-Quelquejeu M, Garbay C, Chen H. Dao P, et al. Among authors: lietha d. Bioorg Med Chem Lett. 2017 Apr 15;27(8):1727-1730. doi: 10.1016/j.bmcl.2017.02.072. Epub 2017 Feb 28. Bioorg Med Chem Lett. 2017. PMID: 28284808

4

Design, Synthesis, and Biological Evaluation of Covalent Inhibitors of Focal Adhesion Kinase (FAK) against Human Malignant Glioblastoma.

Li B, Li Y, Tomkiewicz-Raulet C, Dao P, Lietha D, Yen-Pon E, Du Z, Coumoul X, Garbay C, Etheve-Quelquejeu M, Chen H. Li B, et al. Among authors: lietha d. J Med Chem. 2020 Nov 12;63(21):12707-12724. doi: 10.1021/acs.jmedchem.0c01059. Epub 2020 Oct 29. J Med Chem. 2020. PMID: 33119295 Free article.

5

Synthesis of novel diarylamino-1,3,5-triazine derivatives as FAK inhibitors with anti-angiogenic activity.

Dao P, Jarray R, Le Coq J, Lietha D, Loukaci A, Lepelletier Y, Hadj-Slimane R, Garbay C, Raynaud F, Chen H. Dao P, et al. Among authors: lietha d. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4552-6. doi: 10.1016/j.bmcl.2013.06.038. Epub 2013 Jun 24. Bioorg Med Chem Lett. 2013. PMID: 23845217

6

New insights into FAK structure and function in focal adhesions.

Le Coq J, Acebrón I, Rodrigo Martin B, López Navajas P, Lietha D. Le Coq J, et al. Among authors: lietha d. J Cell Sci. 2022 Oct 15;135(20):jcs259089. doi: 10.1242/jcs.259089. Epub 2022 Oct 14. J Cell Sci. 2022. PMID: 36239192 Review.

7

Structure-Based Design, Synthesis, and Characterization of the First Irreversible Inhibitor of Focal Adhesion Kinase.

Yen-Pon E, Li B, Acebrón-Garcia-de-Eulate M, Tomkiewicz-Raulet C, Dawson J, Lietha D, Frame MC, Coumoul X, Garbay C, Etheve-Quelquejeu M, Chen H. Yen-Pon E, et al. Among authors: lietha d. ACS Chem Biol. 2018 Aug 17;13(8):2067-2073. doi: 10.1021/acschembio.8b00250. Epub 2018 Jun 22. ACS Chem Biol. 2018. PMID: 29897729 Free article.

8

Allosteric regulation of focal adhesion kinase by PIP₂ and ATP.

Zhou J, Bronowska A, Le Coq J, Lietha D, Gräter F. Zhou J, et al. Among authors: lietha d. Biophys J. 2015 Feb 3;108(3):698-705. doi: 10.1016/j.bpj.2014.11.3454. Biophys J. 2015. PMID: 25650936 Free PMC article.

9

Expression, Purification, Crystallisation and X-ray Crystallographic Analysis of a Truncated Form of Human Src Homology 2 Containing Inositol 5-Phosphatase 2.

Le Coq J, Heredia Gallego L, Lietha D. Le Coq J, et al. Among authors: lietha d. Protein J. 2016 Jun;35(3):225-30. doi: 10.1007/s10930-016-9665-y. Protein J. 2016. PMID: 27170292

10

A new layer of phosphoinositide-mediated allosteric regulation uncovered for SHIP2.

Le Coq J, López Navajas P, Rodrigo Martin B, Alfonso C, Lietha D. Le Coq J, et al. Among authors: lietha d. FASEB J. 2021 Aug;35(8):e21815. doi: 10.1096/fj.202100561R. FASEB J. 2021. PMID: 34314064 Free article.

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