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Page 1
Discovery of 6-phenylpyrimido[4,5-b][1,4]oxazines as potent and selective acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors with in vivo efficacy in rodents.
Fox BM, Sugimoto K, Iio K, Yoshida A, Zhang JK, Li K, Hao X, Labelle M, Smith ML, Rubenstein SM, Ye G, McMinn D, Jackson S, Choi R, Shan B, Ma J, Miao S, Matsui T, Ogawa N, Suzuki M, Kobayashi A, Ozeki H, Okuma C, Ishii Y, Tomimoto D, Furakawa N, Tanaka M, Matsushita M, Takahashi M, Inaba T, Sagawa S, Kayser F. Fox BM, et al. Among authors: tomimoto d. J Med Chem. 2014 Apr 24;57(8):3464-83. doi: 10.1021/jm500135c. Epub 2014 Apr 8. J Med Chem. 2014. PMID: 24670009
Pharmacological characterization of [trans-5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl]acetic acid monobenzenesulfonate (JTT-553), a novel acyl CoA:diacylglycerol transferase (DGAT) 1 inhibitor.
Tomimoto D, Okuma C, Ishii Y, Akiyama Y, Ohta T, Kakutani M, Ohkuma Y, Ogawa N. Tomimoto D, et al. Biol Pharm Bull. 2015;38(2):263-9. doi: 10.1248/bpb.b14-00655. Biol Pharm Bull. 2015. PMID: 25747985 Free article.
A Novel TNF-α Converting Enzyme (TACE) Selective Inhibitor JTP-96193 Prevents Insulin Resistance in KK-Ay Type 2 Diabetic Mice and Diabetic Peripheral Neuropathy in Type 1 Diabetic Mice.
Maekawa M, Tadaki H, Tomimoto D, Okuma C, Sano R, Ishii Y, Katsuda Y, Yoshiuchi H, Kakefuda R, Ohta T, Sasase T. Maekawa M, et al. Among authors: tomimoto d. Biol Pharm Bull. 2019;42(11):1906-1912. doi: 10.1248/bpb.b19-00526. Biol Pharm Bull. 2019. PMID: 31685773 Free article.
JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, suppresses food intake and gastric emptying with the elevation of plasma peptide YY and glucagon-like peptide-1 in a dietary fat-dependent manner.
Hata T, Mera Y, Ishii Y, Tadaki H, Tomimoto D, Kuroki Y, Kawai T, Ohta T, Kakutani M. Hata T, et al. Among authors: tomimoto d. J Pharmacol Exp Ther. 2011 Mar;336(3):850-6. doi: 10.1124/jpet.110.176560. Epub 2010 Dec 7. J Pharmacol Exp Ther. 2011. PMID: 21139060
A Case of Acute Type A Aortic Dissection after Coronary Artery Bypass Grafting.
Suzuki H, Kita S, Komagamine M, Tomimoto D, Chiba K, Nawata K, Miyairi T. Suzuki H, et al. Among authors: tomimoto d. Ann Thorac Cardiovasc Surg. 2023 Jun 20;29(3):153-156. doi: 10.5761/atcs.cr.21-00193. Epub 2022 Jan 25. Ann Thorac Cardiovasc Surg. 2023. PMID: 35082190 Free PMC article.