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Administration in fed state but not controlled release in the colon increases oral bioavailability of DF030263, a promising drug candidate for chronic lymphocytic leukemia.
Lee JB, Zang X, Zgair A, Ooi TQ, Foley DW, Voronin G, Kagan L, Soukarieh F, Gao R, Shao H, Soh WT, Kim TH, Kim MG, Yun HY, Wilson AJ, Fischer PM, Gershkovich P. Lee JB, et al. Among authors: foley dw. Eur J Pharm Biopharm. 2021 Aug;165:106-112. doi: 10.1016/j.ejpb.2021.05.006. Epub 2021 May 12. Eur J Pharm Biopharm. 2021. PMID: 33991611
Substituted 4-(thiazol-5-yl)-2-(phenylamino)pyrimidines are highly active CDK9 inhibitors: synthesis, X-ray crystal structures, structure-activity relationship, and anticancer activities.
Shao H, Shi S, Huang S, Hole AJ, Abbas AY, Baumli S, Liu X, Lam F, Foley DW, Fischer PM, Noble M, Endicott JA, Pepper C, Wang S. Shao H, et al. Among authors: foley dw. J Med Chem. 2013 Feb 14;56(3):640-59. doi: 10.1021/jm301475f. Epub 2013 Jan 25. J Med Chem. 2013. PMID: 23301767 Free PMC article.
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