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Mutations in UBA3 confer resistance to the NEDD8-activating enzyme inhibitor MLN4924 in human leukemic cells.
Xu GW, Toth JI, da Silva SR, Paiva SL, Lukkarila JL, Hurren R, Maclean N, Sukhai MA, Bhattacharjee RN, Goard CA, Medeiros B, Gunning PT, Dhe-Paganon S, Petroski MD, Schimmer AD. Xu GW, et al. Among authors: gunning pt. PLoS One. 2014 Apr 1;9(4):e93530. doi: 10.1371/journal.pone.0093530. eCollection 2014. PLoS One. 2014. PMID: 24691136 Free PMC article.
Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities.
Fletcher S, Singh J, Zhang X, Yue P, Page BD, Sharmeen S, Shahani VM, Zhao W, Schimmer AD, Turkson J, Gunning PT. Fletcher S, et al. Among authors: gunning pt. Chembiochem. 2009 Aug 17;10(12):1959-64. doi: 10.1002/cbic.200900172. Chembiochem. 2009. PMID: 19644994 Free PMC article. No abstract available.
Targeting the ubiquitin E1 as a novel anti-cancer strategy.
Xu W, Lukkarila JL, da Silva SR, Paiva SL, Gunning PT, Schimmer AD. Xu W, et al. Among authors: gunning pt. Curr Pharm Des. 2013;19(18):3201-9. doi: 10.2174/1381612811319180004. Curr Pharm Des. 2013. PMID: 23151135 Review.
127 results