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Mutations in UBA3 confer resistance to the NEDD8-activating enzyme inhibitor MLN4924 in human leukemic cells.
Xu GW, Toth JI, da Silva SR, Paiva SL, Lukkarila JL, Hurren R, Maclean N, Sukhai MA, Bhattacharjee RN, Goard CA, Medeiros B, Gunning PT, Dhe-Paganon S, Petroski MD, Schimmer AD. Xu GW, et al. Among authors: lukkarila jl. PLoS One. 2014 Apr 1;9(4):e93530. doi: 10.1371/journal.pone.0093530. eCollection 2014. PLoS One. 2014. PMID: 24691136 Free PMC article.
Targeting the ubiquitin E1 as a novel anti-cancer strategy.
Xu W, Lukkarila JL, da Silva SR, Paiva SL, Gunning PT, Schimmer AD. Xu W, et al. Among authors: lukkarila jl. Curr Pharm Des. 2013;19(18):3201-9. doi: 10.2174/1381612811319180004. Curr Pharm Des. 2013. PMID: 23151135 Review.
A selective inhibitor of the UFM1-activating enzyme, UBA5.
da Silva SR, Paiva SL, Bancerz M, Geletu M, Lewis AM, Chen J, Cai Y, Lukkarila JL, Li H, Gunning PT. da Silva SR, et al. Among authors: lukkarila jl. Bioorg Med Chem Lett. 2016 Sep 15;26(18):4542-4547. doi: 10.1016/j.bmcl.2015.10.015. Epub 2015 Oct 8. Bioorg Med Chem Lett. 2016. PMID: 27520940
Identification of Purine-Scaffold Small-Molecule Inhibitors of Stat3 Activation by QSAR Studies.
Shahani VM, Yue P, Haftchenary S, Zhao W, Lukkarila JL, Zhang X, Ball D, Nona C, Gunning PT, Turkson J. Shahani VM, et al. Among authors: lukkarila jl. ACS Med Chem Lett. 2011 Jan 13;2(1):79-84. doi: 10.1021/ml100224d. Epub 2010 Oct 25. ACS Med Chem Lett. 2011. Retraction in: ACS Med Chem Lett. 2023 Sep 19;14(10):1482. doi: 10.1021/acsmedchemlett.3c00405 PMID: 21243039 Free PMC article. Retracted.