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Mutations in UBA3 confer resistance to the NEDD8-activating enzyme inhibitor MLN4924 in human leukemic cells.
Xu GW, Toth JI, da Silva SR, Paiva SL, Lukkarila JL, Hurren R, Maclean N, Sukhai MA, Bhattacharjee RN, Goard CA, Medeiros B, Gunning PT, Dhe-Paganon S, Petroski MD, Schimmer AD. Xu GW, et al. Among authors: paiva sl. PLoS One. 2014 Apr 1;9(4):e93530. doi: 10.1371/journal.pone.0093530. eCollection 2014. PLoS One. 2014. PMID: 24691136 Free PMC article.
Targeting the ubiquitin E1 as a novel anti-cancer strategy.
Xu W, Lukkarila JL, da Silva SR, Paiva SL, Gunning PT, Schimmer AD. Xu W, et al. Among authors: paiva sl. Curr Pharm Des. 2013;19(18):3201-9. doi: 10.2174/1381612811319180004. Curr Pharm Des. 2013. PMID: 23151135 Review.
A selective inhibitor of the UFM1-activating enzyme, UBA5.
da Silva SR, Paiva SL, Bancerz M, Geletu M, Lewis AM, Chen J, Cai Y, Lukkarila JL, Li H, Gunning PT. da Silva SR, et al. Among authors: paiva sl. Bioorg Med Chem Lett. 2016 Sep 15;26(18):4542-4547. doi: 10.1016/j.bmcl.2015.10.015. Epub 2015 Oct 8. Bioorg Med Chem Lett. 2016. PMID: 27520940
Targeted protein degradation: elements of PROTAC design.
Paiva SL, Crews CM. Paiva SL, et al. Curr Opin Chem Biol. 2019 Jun;50:111-119. doi: 10.1016/j.cbpa.2019.02.022. Epub 2019 Apr 17. Curr Opin Chem Biol. 2019. PMID: 31004963 Free PMC article. Review.
Bugging out for jet fuel.
Paiva SL. Paiva SL. Nat Rev Chem. 2022 Aug;6(8):520. doi: 10.1038/s41570-022-00415-4. Nat Rev Chem. 2022. PMID: 37118009 No abstract available.
44 results