Ernst A - Search Results

1

Prediction and experimental characterization of nsSNPs altering human PDZ-binding motifs.

Gfeller D, Ernst A, Jarvik N, Sidhu SS, Bader GD. Gfeller D, et al. Among authors: ernst a. PLoS One. 2014 Apr 10;9(4):e94507. doi: 10.1371/journal.pone.0094507. eCollection 2014. PLoS One. 2014. PMID: 24722214 Free PMC article.

2

Coevolution of PDZ domain-ligand interactions analyzed by high-throughput phage display and deep sequencing.

Ernst A, Gfeller D, Kan Z, Seshagiri S, Kim PM, Bader GD, Sidhu SS. Ernst A, et al. Mol Biosyst. 2010 Oct;6(10):1782-90. doi: 10.1039/c0mb00061b. Epub 2010 Aug 11. Mol Biosyst. 2010. PMID: 20714644

3

The multiple-specificity landscape of modular peptide recognition domains.

Gfeller D, Butty F, Wierzbicka M, Verschueren E, Vanhee P, Huang H, Ernst A, Dar N, Stagljar I, Serrano L, Sidhu SS, Bader GD, Kim PM. Gfeller D, et al. Among authors: ernst a. Mol Syst Biol. 2011 Apr 26;7:484. doi: 10.1038/msb.2011.18. Mol Syst Biol. 2011. PMID: 21525870 Free PMC article.

4

A structural portrait of the PDZ domain family.

Ernst A, Appleton BA, Ivarsson Y, Zhang Y, Gfeller D, Wiesmann C, Sidhu SS. Ernst A, et al. J Mol Biol. 2014 Oct 23;426(21):3509-19. doi: 10.1016/j.jmb.2014.08.012. Epub 2014 Aug 23. J Mol Biol. 2014. PMID: 25158098

5

Structural and functional characterization of a ubiquitin variant engineered for tight and specific binding to an alpha-helical ubiquitin interacting motif.

Manczyk N, Yates BP, Veggiani G, Ernst A, Sicheri F, Sidhu SS. Manczyk N, et al. Among authors: ernst a. Protein Sci. 2017 May;26(5):1060-1069. doi: 10.1002/pro.3155. Epub 2017 Mar 24. Protein Sci. 2017. PMID: 28276594 Free PMC article.

6

Comprehensive analysis of all evolutionary paths between two divergent PDZ domain specificities.

Teyra J, Ernst A, Singer A, Sicheri F, Sidhu SS. Teyra J, et al. Among authors: ernst a. Protein Sci. 2020 Feb;29(2):433-442. doi: 10.1002/pro.3759. Epub 2019 Nov 14. Protein Sci. 2020. PMID: 31654425 Free PMC article.

7

Comprehensive Assessment of the Relationship Between Site^-2 Specificity and Helix α2 in the Erbin PDZ Domain.

Teyra J, McLaughlin M, Singer A, Kelil A, Ernst A, Sicheri F, Sidhu SS. Teyra J, et al. Among authors: ernst a. J Mol Biol. 2021 Sep 3;433(18):167115. doi: 10.1016/j.jmb.2021.167115. Epub 2021 Jun 24. J Mol Biol. 2021. PMID: 34171344

8

Dimerization of a ubiquitin variant leads to high affinity interactions with a ubiquitin interacting motif.

Manczyk N, Veggiani G, Gish GD, Yates BP, Ernst A, Sidhu SS, Sicheri F. Manczyk N, et al. Among authors: ernst a. Protein Sci. 2019 May;28(5):848-856. doi: 10.1002/pro.3593. Epub 2019 Mar 12. Protein Sci. 2019. PMID: 30793400 Free PMC article.

9

Rapid evolution of functional complexity in a domain family.

Ernst A, Sazinsky SL, Hui S, Currell B, Dharsee M, Seshagiri S, Bader GD, Sidhu SS. Ernst A, et al. Sci Signal. 2009 Sep 8;2(87):ra50. doi: 10.1126/scisignal.2000416. Sci Signal. 2009. PMID: 19738200

10

A strategy for modulation of enzymes in the ubiquitin system.

Ernst A, Avvakumov G, Tong J, Fan Y, Zhao Y, Alberts P, Persaud A, Walker JR, Neculai AM, Neculai D, Vorobyov A, Garg P, Beatty L, Chan PK, Juang YC, Landry MC, Yeh C, Zeqiraj E, Karamboulas K, Allali-Hassani A, Vedadi M, Tyers M, Moffat J, Sicheri F, Pelletier L, Durocher D, Raught B, Rotin D, Yang J, Moran MF, Dhe-Paganon S, Sidhu SS. Ernst A, et al. Science. 2013 Feb 1;339(6119):590-5. doi: 10.1126/science.1230161. Epub 2013 Jan 3. Science. 2013. PMID: 23287719 Free PMC article.

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