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A 17-residue sequence from the matrix metalloproteinase-9 (MMP-9) hemopexin domain binds α4β1 integrin and inhibits MMP-9-induced functions in chronic lymphocytic leukemia B cells.
Ugarte-Berzal E, Bailón E, Amigo-Jiménez I, Vituri CL, del Cerro MH, Terol MJ, Albar JP, Rivas G, García-Marco JA, García-Pardo A. Ugarte-Berzal E, et al. Among authors: bailon e. J Biol Chem. 2012 Aug 10;287(33):27601-13. doi: 10.1074/jbc.M112.354670. Epub 2012 Jun 22. J Biol Chem. 2012. PMID: 22730324 Free PMC article. Clinical Trial.
A catalytically inactive gelatinase B/MMP-9 mutant impairs homing of chronic lymphocytic leukemia cells by altering migration regulatory pathways.
Bailón E, Aguilera-Montilla N, Gutiérrez-González A, Ugarte-Berzal E, Van den Steen PE, Opdenakker G, García-Marco JA, García-Pardo A. Bailón E, et al. Biochem Biophys Res Commun. 2018 Jan 1;495(1):124-130. doi: 10.1016/j.bbrc.2017.10.129. Epub 2017 Nov 4. Biochem Biophys Res Commun. 2018. PMID: 29080742
MMP-9 affects gene expression in chronic lymphocytic leukemia revealing CD99 as an MMP-9 target and a novel partner in malignant cell migration/arrest.
Aguilera-Montilla N, Bailón E, Uceda-Castro R, Ugarte-Berzal E, Santos A, Gutiérrez-González A, Pérez-Sánchez C, Van den Steen PE, Opdenakker G, García-Marco JA, García-Pardo A. Aguilera-Montilla N, et al. Among authors: bailon e. Oncogene. 2019 Jun;38(23):4605-4619. doi: 10.1038/s41388-019-0744-3. Epub 2019 Feb 13. Oncogene. 2019. PMID: 30760844 Free article.
α4β1 integrin associates with VEGFR2 in CLL cells and contributes to VEGF binding and intracellular signaling.
Gutiérrez-González A, Aguilera-Montilla N, Ugarte-Berzal E, Bailón E, Cerro-Pardo I, Sánchez-Maroto C, García-Campillo L, García-Marco JA, García-Pardo A. Gutiérrez-González A, et al. Among authors: bailon e. Blood Adv. 2019 Jul 23;3(14):2144-2148. doi: 10.1182/bloodadvances.2019000019. Blood Adv. 2019. PMID: 31307975 Free PMC article.
44 results